Gomez, AlexiaSánchez-Román Rojas, InésGomez, JoseNaudí, AlbaPushparaj, CharumatiPortero-Otín, ManuelLópez Torres, MónicaPamplona, ReinaldBarja De Quiroga Losada, Gustavo2024-02-012024-02-012013An. Real Acad. Farm. Vol 79, Nº4 (2013), pag. 613-6331697-4271https://hdl.handle.net/20.500.14352/97863A new mammalian longevity model based on ß-adrenergic signaling interruption at the level of adenylyl cyclase has reported decreased bone and heart aging and mean and maximum longevity increases in AC5KO mice (1). We decided to mimic this model in male Wistar rats treated with the ß-blocker atenolol in the drinking water and to check if an oxidative stress decrease could be involved. Atenolol treatment did not modify heart mitROS generation rate and mitDNA oxidative damage but significantly decreased global peroxidizability index of mitochondrial membranes, as well as protein lipoxidation, probably mediated by changes in elongases and desaturases activities.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Reduction in mitochondrialmembrane peroxidizability index and protein lipoxidation levels in therat heart after ß-adrenergic receptor signaling interruption with the ß-blocker atenololReducción en el índice de peroxidizabilidad de la membrana mitocondrial y niveles de lipoxidación proteícos en el corazón de la rata después de la interrupción de la señalización del receptor betaadrenérgico con el betabloqueante atenololjournal articlehttps://analesranf.com/wp-content/uploads/2013/79_04/an7904/79_04.html#p=97open accessCiencias Biomédicas24 Ciencias de la Vida