Jiménez Duro, MiguelBarranco García, RosaMartínez Fernández, MarcosAsenjo Filgueira, BelénMartínez, José I.Cuervo Rodríguez, María RocíoMuñoz Bonilla, AlexandraFernández García, MartaSegura Castedo, José Luis2024-12-202024-12-202024-12-1310.1021/acsami.4c16938https://hdl.handle.net/20.500.14352/113103The rise of antibiotic-resistant bacteria has created an urgent need for antibacterial materials. One of the most widespread strategies involves the covalent attachment of ionic moieties, which can, however, compromise the quality of the final polymers. Herein, we report the synthesis of ionic covalent organic framework nanoparticles via click postsynthetic modification. The material is highly dispersible and exhibits excellent antibacterial properties against both Gram-positive and Gram-negative bacteria. Furthermore, biobased polymer/COF nanocomposites were produced through casting/melt compression and melt electrospinning, retaining the antibacterial properties without sacrificing the thermal stability of the polymers. Ongoing studies in our laboratories are exploring the potential application of these composites in biomedical devices.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://doi.org/10.1021/acsami.4c16938https://pubs.acs.org/doi/10.1021/acsami.4c16938restricted access547Covalent Organic FrameworkNanocompositesBiobased PolymersPoly(lactic acid)AntibacterialCienciasQuímicaQuímica orgánica (Química)Materiales23 Química2306 Química Orgánica2304.03 Polímeros Compuestos