Cantú-Germano, E.Herreros De Tejada López, AlbeMarín Gabriel, José CarlosJOSÉ BENJAMÍN DÍAZ TASENDEDíaz Tasende, José Benjamín2026-01-202026-01-202025Cantú-Germano E, Fernández-Esparrach G, De Tejada AH, Marín-Gabriel JC, Uchima H, Ramos-Zabala F, et al. Poor agreement between biopsies and endoscopic submucosal dissection specimens of Esophageal and Gastric Epithelial Lesions in a western setting. Digestive and Liver Disease 2025;57:1006–14. https://doi.org/10.1016/j.dld.2025.02.025.10.1016/j.dld.2025.02.025https://hdl.handle.net/20.500.14352/130623Background Endoscopic forceps biopsy is the primary method for obtaining mucosal tissues, but can lead to false negatives. Aims To assess the agreement between endoscopic biopsies and submucosal dissection specimens in esophageal and gastric epithelial lesions and to identify factors associated. Methods Cross-sectional study using data from the Spanish national multicenter endoscopic submucosal dissection register. Patients, lesions and technical characteristics were prospectively collected. Prognostic factors for discrepancies were analyzed. Results 604 endoscopic submucosal dissection with previous biopsies were performed between January 2016 and December 2023 across 32 centers. 48.7% presented disagreement between biopsies and endoscopic submucosal dissection; specifically, 40.4% were underestimated by endoscopic biopsy. Carcinoma was detected in 270 endoscopic submucosal dissection specimens, with 54.8% not suspected on the initial biopsy. The carcinomas already diagnosed with the biopsy presented more submucosal and lymphovascular invasion. Notably, a larger lesion (≥ 22 mm) was a significant predictor for histological upstaging. Conclusions The high rate of disagreement between endoscopic forceps biopsy and endoscopic submucosal dissection highlights biopsies limitations in accurately diagnosing esophageal and gastric epithelial lesions. In this setting, endoscopic submucosal dissection should be used not only as a treatment option, but also as a valuable diagnostic tool.engjournal articlehttps://doi.org/10.1016/j.dld.2025.02.025https://www.sciencedirect.com/science/article/pii/S1590865825002750?via%3Dihubrestricted accessEndoscopic submucosal dissectionEsophageal neoplasmsEsophageal neoplasmsGastroenterología y hepatología3205.03 Gastroenterología