Rojo, M. ÁngelesGarrosa, ManuelJimenez López, PilarGarcía Recio, VeronicaCórdoba Díaz, DamiánCórdoba Díaz, Manuel2023-06-172023-06-172020-08-222072-665110.3390/toxins12090542https://hdl.handle.net/20.500.14352/7312Abstract: The safety of concentrated food complements intake is a major health concern. It has been well established that green tea polyphenols (GTPs) consumption promotes healthy effects. However, the ingestion of large amounts of GTPs is a matter of controversy due to reported adverse effects. We underwent a preliminary exploration of the effects of the oral administration of a standardized concentrated GTPs preparation on mice which suffered from reversible intestinal derangement promoted by sublethal amounts of the antiribosomal lectin ebulin f from dwarf elder (Sambucus ebulus L.). Neither independent oral administration of 30 mg/kg body weight Polyphenon 60 nor intraperitoneal administration of 2.5 mg/kg body weight ebulin f triggered lethal toxicity. In contrast, the simultaneous administration of these same doses of both Polyphenon 60 and ebulin f triggered an important and unexpected synergistic toxic action featured by the biphasic reduction of weight, which continued after eight days, reaching a reduction of 40%. Lethality appeared 2 days after the onset of the combined treatment and reached more than 50% after 10 days.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal articlehttps://doi.org/10.3390/toxins12090542open access615.01/.03615.9Green tea polyphenolsSambucus ebulusEbulin fRIPLectinRibosome-inactivating proteinricinFarmacología (Farmacia)Toxicología (Farmacia)3209 Farmacología6113.05 Tratamiento de la Drogadicción