Sex-Related Disparities in the Incidence and Outcomes of Ischemic Stroke among Type 2 Diabetes Patients. A Matched-Pair Analysis Using the Spanish National Hospital Discharge Database for Years 2016

López de Andrés, AnaJiménez García, RodrigoHernández Barrera, ValentínJiménez Trujillo, IsabelZamorano León, José J.Carabantes Alarcón, DavidLópez Herranz, MartaMiguel Yanes, José María deMiguel Díez, Javier de2023-06-172023-06-172021-04-011660-460110.3390/ijerph18073659https://hdl.handle.net/20.500.14352/6937Background: To analyze the incidence, use of therapeutic procedures, and in-hospital outcomes among patients suffering an ischemic stroke (IS) according to the presence of type 2 diabetes mellitus (T2DM) in Spain (2016–2018) and to assess the existence of sex differences. Methods: Matched-pair analysis using the Spanish National Hospital discharge. Results: IS was coded in 92,524 men and 79,731 women (29.53% with T2DM). The adjusted incidence of IS (IRR 2.02; 95% CI 1.99–2.04) was higher in T2DM than non-T2DM subjects, with higher IRRs in both sexes. Men with T2DM had a higher incidence of IS than T2DM women (IRR 1.54; 95% CI 1.51–1.57). After matching patients with T2DM, those with other comorbid conditions, however, significantly less frequently received endovascular thrombectomy and thrombolytic therapy. In-hospital mortality (IHM) was lower among T2DM men than matched non-T2DM men (8.23% vs. 8.71%; p < 0.001). Women with T2DM had a higher IHM rate than T2DM men (11.5% vs. 10.20%; p = 0.004). After adjusting for confounders, women with T2DM had a 12% higher mortality risk than T2DM men (OR 1.12; 95% CI 1.04–1.21). Conclusions: T2DM is associated with higher incidence of IS in both sexes. Men with T2DM have a higher incidence rates of IS than T2DM women. Women with T2DM have a higher risk of dying in the hospital.engAtribución 3.0 EspañaSex-Related Disparities in the Incidence and Outcomes of Ischemic Stroke among Type 2 Diabetes Patients. A Matched-Pair Analysis Using the Spanish National Hospital Discharge Database for Years 2016–2018journal articlehttps://doi.org/10.3390/ijerph18073659https://www.mdpi.com/1660-4601/18/7/3659/htmopen accessischemic stroketype 2 diabetes mellitussex differencesincidencein-hospital mortalityDietética y nutrición (Medicina)EndocrinologíaNeurociencias (Medicina)Medicina Física y Rehabilitación3206 Ciencias de la Nutrición3205.02 Endocrinología2490 Neurociencias3204.04 Rehabilitación (Medica)