Guerra Pérez, NataliaVega-Sendino, MaríaPérez-Morgado, IsabelRamos, EdurneSoto, ManuelGonzalez, VictorMartín, ElenaIbba, Michael2024-02-012024-02-012010Guerra Natalia, Vega-Sendino María, Pérez-Morgado M. Isabel, Ramos Edurne, Soto Manuel, Gonzalez Víctor M. and Martín M. Elena (2011), Identification and functional characterization of a poly(A)-binding protein from Leishmania infantum (LiPABP), FEBS Letters, 585, doi: 10.1016/j.febslet.2010.11.0420014-579310.1016/j.febslet.2010.11.042https://hdl.handle.net/20.500.14352/97966Gene expression regulation in Leishmania has been related to post-transcriptional events involving mainly sequences present in the 5′ and 3′ untranslated regions. PABPs are high-affinity poly(A)-binding proteins that are implicated in the regulation of translation initiation, RNA stability and other important biological processes. We describe a PABP from Leishmania infantum (LiPABP) that shows a very high homology with PABPs from other eukaryotic organisms, including mammals and other parasites. LiPABP conserves the main domains present in other PABPs, maintains poly(A)-binding properties and is phosphorylated by p38 mitogen-activated protein kinase. Using the sera from dogs infected with L. infantum, we demonstrate that LiPABP is expressed in L. infantum promastigotes.engjournal article1873-3468https://doi.org/10.1016/j.febslet.2010.11.042open accessPoly(A)-binding proteinTranslation regulationLeishmania infantumBiología24 Ciencias de la Vida