Lozano, BlancaTeresa, JavierFernández López, IsraelTortosa, Mariola2026-02-052026-02-052025-10-31Lozano, Blanca, et al. «Cyclopropylmethyl Boronic Esters as General Reagents in Transition-Metal Catalyzed Homoallylation Reactions». Journal of the American Chemical Society, vol. 147, n.o 45, noviembre de 2025, pp. 41221-28. DOI.org (Crossref), https://doi.org/10.1021/jacs.5c15781.10.1021/jacs.5c15781https://hdl.handle.net/20.500.14352/131542Herein we disclose the use of cyclopropylmethyl boronates as general reagents in Negishi-type homoallylation reactions. This strategy provides a novel approach to generate enantioenriched homoallyl-Zn species through boron-to-zinc transmetalation. Subsequent sp2–sp3 cross-coupling offers a platform for the preparation of arenes, ketones, and 1,5-dienes containing a chiral homoallylic scaffold. The method has been applied to the late-stage functionalization of known drugs and the preparation of precursors of biologically relevant compounds. Mechanistic experiments and DFT calculations provide insight into the transmetalation/ring-opening sequence.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://doi.org/10.1021/jacs.5c15781https://pubs.acs.org/doi/10.1021/jacs.5c15781open access547AldehydesCross coupling reactionHydrocarbonsOrganic compoundsReagentsQuímica orgánica (Química)2306 Química Orgánica