Sánchez Pérez, Silvia NereaFierravanti, LudovicaNuñez, JavierVignoletti, FabioGonzález Zamora, MaríaSantamaria, SilviaSuárez Sancho, SusanaFernández Santos, Maria EugeniaFiguero Ruiz, ElenaHerrera González, DavidSanz Alonso, Mariano2024-02-092024-02-092020Sánchez N, Fierravanti L, Núñez J, Vignoletti F, González-Zamora M, Santamaría S, Suárez-Sancho S, Fernández-Santos ME, Figuero E, Herrera D, García-Sanz JA, Sanz M. Periodontal regeneration using a xenogeneic bone substitute seeded with autologous periodontal ligament-derived mesenchymal stem cells: A 12-month quasi-randomized controlled pilot clinical trial. J Clin Periodontol. 2020 Nov;47(11):1391-1402. doi: 10.1111/jcpe.13368. PMID: 32946590.1600-051X10.1111/jcpe.13368.https://hdl.handle.net/20.500.14352/100900Aim: To evaluate the safety and efficacy of autologous periodontal ligament-derived mesenchymal stem cells (PDL-MSCs) embedded in a xenogeneic bone substitute (XBS) for the regenerative treatment of intra-bony periodontal defects. Material and methods: This quasi-randomized controlled pilot phase II clinical trial included patients requiring a tooth extraction and presence of one intra-bony lesion (1-2 walls). Patients were allocated to either the experimental (XBS + 10 × 106 PDL-MSCs/100 mg) or the control group (XBS). Clinical and radiographical parameters were recorded at baseline, 6, 9 and 12 months. The presence of adverse events was also evaluated. Chi-square, Student's t test, Mann-Whitney U, repeated-measures ANOVA and regression models were used. Results: Twenty patients were included. No serious adverse events were reported. Patients in the experimental group (n = 9) showed greater clinical attachment level (CAL) gain (1.44, standard deviation [SD] = 1.87) and probing pocket depth (PPD) reduction (2.33, SD = 1.32) than the control group (n = 10; CAL gain = 0.88, SD = 1.68, and PPD reduction = 2.10, SD = 2.46), without statistically significant differences. Conclusion: The application of PDL-MSCs to XBS for the treatment of one- to two-wall intra-bony lesions was safe and resulted in low postoperative morbidity and appropriate healing, although its additional benefit, when compared with the XBS alone, was not demonstrated.engjournal articlehttps://doi.org/10.1111/jcpe.1336832946590https://onlinelibrary.wiley.com/doi/10.1111/jcpe.13368restricted access616.314.17-008.1Cell therapyMesenchymal stem cellsPeriodontal ligamentPeriodontal regenerationTissue engineering.Odontología (Odontología)Periodoncia32 Ciencias Médicas