Olmedo, Dionisio A.López-Pérez, José Luisdel Olmo, EstherBedoya Del Olmo, Luis MiguelSancho, RocíoAlcamí, JoséMuñoz, EduardoSan Feliciano, ArturoGupta, Mahabir P.2023-06-182023-06-182017-02-19Olmedo, D. A., López-Pérez, J. L., Del Olmo, E. et al. «Neoflavonoids as Inhibitors of HIV-1 Replication by Targeting the Tat and NF-κB Pathways». Molecules, vol. 22, n.o 2, febrero de 2017, p. 321. DOI.org (Crossref), https://doi.org/10.3390/molecules22020321.1420-304910.3390/molecules22020321https://hdl.handle.net/20.500.14352/19242Twenty-eight neoflavonoids have been prepared and evaluated in vitro against HIV-1. Antiviral activity was assessed on MT-2 cells infected with viral clones carrying the luciferase reporter gene. Inhibition of HIV transcription and Tat function were tested on cells stably transfected with the HIV-LTR and Tat protein. Seven 4-phenylchromen-2 one derivatives showed HIV transcriptional inhibitory activity but only the phenylchrome-2-one 10 inhibited NF-κB and displayed anti-Tat activity simultaneously. Compounds 10, 14, and 25, inhibited HIV replication in both targets at concentrations <25 µM. The assays of these synthetic 4 phenylchromen-2-ones may aid in the investigation of some aspects of the anti-HIV activity of such compounds and could serve as a scaffold for designing better anti-HIV compounds, which may lead to a potential anti-HIV therapeutic drug.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal articlehttps://doi.org/10.3390/molecules22020321https://www.mdpi.com/1420-3049/22/2/321open access615.011Neoflavonoids4-phenyl-chromen-oneAIDSTat proteinNF-κB inhibitionAnti-HIV activityFarmacología (Farmacia)Química farmaceútica3209 Farmacología2390 Química Farmacéutica