Zuluaga, SusanaGutiérrez Uzquiza, ÁlvaroBragado, PalomaAlvarez-Barrientos, AlbertoBenito De Las Heras, Manuel R.Nebreda, Angel RPorras Gallo, María Almudena2024-01-122024-01-122007Fraguas-Sánchez AI, Fernández-Carballido A, Martin-Sabroso C, Torres-Suárez AI. Stability characteristics of cannabidiol for the design of pharmacological, biochemical and pharmaceutical studies. Journal of Chromatography B 2020;1150:122188. https://doi.org/10.1016/j.jchromb.2020.122188.0014-579310.1016/j.febslet.2007.06.078https://hdl.handle.net/20.500.14352/92697The small GTP-ase Rac-1 can trigger p38 MAPK activation and, in turn, p38alpha can regulate signalling pathways that potentially impinge on Rac-1 activity. We have investigated the cross-talk between p38alpha and Rac-1 and found that p38alpha regulates the association between Rac-1 and caveolin-1 in serum-deprived cardiomyocytes. This interaction depends on cell attachment and correlates with higher levels of active Rac-1. Actin organization might regulate the formation of Rac-1-caveolin-1 complexes. In contrast, the Rac-1-caveolin-1 interaction is almost undetectable in the presence of serum, where Rac-1 activity is negatively regulated by p38alpha. Our results indicate that p38alpha can differentially contribute to Rac-1 activation depending on the presence of serum.engAttribution-NonCommercial-NoDerivatives 4.0 Internationaljournal article1873-3468https://doi.org/10.1016/j.febslet.2007.06.078https://febs.onlinelibrary.wiley.com/doi/10.1016/j.febslet.2007.06.078restricted access665p38 MAPKCardiomyocyteActinAdhesionCaveolin-1Rac-1Bioquímica (Farmacia)23 Química