García Gargallo, M.Zurlohe, MartinaMontero Solís, EduardoAlonso Álvarez, Bettina MaríaSerrano, JorgeSanz Alonso, MarianoHerrera González, David2024-02-022024-02-022017-11García-Gargallo M, Zurlohe M, Montero E, Alonso B, Serrano J, Sanz M, Herrera D. Evaluation of new chlorhexidine- and cetylpyridinium chloride-based mouthrinse formulations adjunctive to scaling and root planing: pilot study. Int J Dent Hyg. 2017 Nov;15(4):269-2791601-502910.1111/idh.12254https://hdl.handle.net/20.500.14352/98183Objective: To compare the effect of two newly formulated chlorhexidine (CHX) and cetylpyridinium chloride (CPC) mouthrinses after scaling and root planing (SRP) in terms of clinical, microbiological, patient-based variables and adverse events, with a positive control with the same active components, already marketed and tested. Methods: A pilot, randomized clinical trial, double-blind, parallel design with 1-month follow-up was conducted. Chronic periodontitis patients requiring non-surgical periodontal therapy were enrolled and randomly assigned to: (i) SRP and test-1 (new reformulation: 0.12% CHX and 0.05% CPC); (ii) SRP and test-2 (new formulation: 0.03% CHX and 0.05% CPC); or (iii) SRP and positive control (commercial product: 0.12% CHX and 0.05% CPC). All variables were evaluated at baseline and 1 month after SRP. Quantitative variables were compared by means of anova or Kruskal-Wallis test and qualitative variables by chi-square or McNemar tests. Results: Thirty patients (10 per group) were included. After 1 month, there were significant differences among groups in plaque levels (P = 0.016) as test-1 showed less sites with plaque than test-2 (31.15% [standard error-SE 2.21%] versus 49.39% [SE 4.60%), respectively). No significant differences were found for global patient perception of the product or in adverse effects. Test groups showed better results in levels and proportions (P = 0.022) of Capnocytophaga spp. Conclusions: Within the limitations of this pilot study, it can be concluded that the newly formulated 0.12% CHX and 0.05% CPC mouthrinse showed larger plaque level reductions, without showing more adverse effects, when compared to the other two mouthrinses, after SRP.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article1601-5037https//doi.org/10.1111/idh.1225427762095https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/idh.12254open access616.314616.314.17-008.1615.07615.46AntisepticsCetylpyridinium chlorideChlorhexidineDental plaqueMouthrinseNon-surgical periodontal therapyScaling and root planingCiencias BiomédicasOdontología (Odontología)PeriodonciaAparatos y material odontológicosMedicamentosAnálisis clínicos32 Ciencias Médicas3213.13 Ortodoncia-Estomatología3209.03 Evaluación de Medicamentos