Castaño Joaqui, Oscar GabrielJiménez Ortega, LauraCerero Lapiedra, RocíoDomínguez Gordillo, Adelaida Africa2025-01-282025-01-282024-12-13Castaño-Joaqui OG, Jiménez Ortega L, Cerero Lapiedra R, Domínguez Gordillo AÁ. Burning Mouth Syndrome Underlying Factors: A Roadmap From a Network Perspective. Oral Dis. 2024 Dec 13. doi: 10.1111/odi.152191354-523X10.1111/odi.15219https://hdl.handle.net/20.500.14352/116575Objective: To investigate the relationship between biological, psychological, and social factors underlying Burning Mouth Syndrome (BMS). Subjects and methods: A case (n = 40) and control (n = 42) study containing 80 variables was examined using two network models based on regularized partial correlations (n = 82). Results: The structure of the associative pathways with the BMS was revealed. Direct associations involved Gastrointestinal Alterations (0.23), Vitamin D Deficiency (0.29), Musculoskeletal Alterations (0.29), Symptom Severity Score 2 (SSS2) (0.22), Cortisol Variation (0.10), Interpersonal Sensitivity (0.04), Hostility (0.03). Global Severity Index, Symptom Severity Score 1, Psychoticism, Obsession-Compulsion, Depression, Anxiety, and Somatization were indirectly related. The SSS2 was the most influential on BMS accuracy. Conclusions: Gastrointestinal alterations and vitamin D deficiency show a significant influence on BMS while cortisol mediates in multiple associative pathways between musculoskeletal alterations, gastrointestinal alterations, vitamin D deficiency, non-restorative sleep, fatigue, and cognitive problems. In addition to anxiety and depression, psychoticism, interpersonal sensitivity, and hostility stand out as psychological factors that seem to be related to a lack of vitamin D. None of the factors studied seem to have a relevant predictive potential for BMS, except for nonspecific symptoms of central sensitization.engAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/journal article1601-0825https://doi.org/10.1111/odi.1521939673150https://onlinelibrary.wiley.com/doi/10.1111/odi.15219https://pubmed.ncbi.nlm.nih.gov/39673150/open access616.31:159.922.2616.31: 572.1/.4616.31:316.3Central sensitizationGastrointestinal diseasesGlucocorticoidsNetwork analysesPsychosocial factorsVitamin DOdontología preventivaPsicología (Psicología)Microbiología médicaPsicología Social (Sociología)3213.13 Ortodoncia-Estomatología3201.04 Patología Clínica3201.05 Psicología Clínica2410 Biología Humana5206 Características de la Población