Fiyouzi Alipour, TaraPeláez Prestel, Héctor FernandoReyes Manzanas, RaquelLafuente Duarte, María EstherReche Gallardo, Pedro AntonioRenaudineau, Yves2024-01-092024-01-092023-04-25Fiyouzi, T., Peláez Prestel, H. F., Reyes Manzanas, R. et al. «Enhancing Regulatory T Cells to Treat Inflammatory and Autoimmune Diseases». International Journal of Molecular Sciences, vol. 24, n.o 9, abril de 2023, p. 7797. DOI.org (Crossref), https://doi.org/10.3390/ijms24097797.1422-00671661-659610.3390/ijms24097797https://hdl.handle.net/20.500.14352/92108Regulatory T cells (Tregs) control immune responses and are essential to maintain immune homeostasis and self-tolerance. Hence, it is no coincidence that autoimmune and chronic inflammatory disorders are associated with defects in Tregs. These diseases have currently no cure and are treated with palliative drugs such as immunosuppressant and immunomodulatory agents. Thereby, there is a great interest in developing medical interventions against these diseases based on enhancing Treg cell function and numbers. Here, we give an overview of Treg cell ontogeny and function, paying particular attention to mucosal Tregs. We review some notable approaches to enhance immunomodulation by Tregs with therapeutic purposes including adoptive Treg cell transfer therapy and discuss relevant clinical trials for inflammatory bowel disease. We next introduce ways to expand mucosal Tregs in vivo using microbiota and dietary products that have been the focus of clinical trials in various autoimmune and chronic-inflammatory diseases.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps//doi.org/10.3390/ijms2409779737175505https://www.mdpi.com/1422-0067/24/9/7797open access612.017Regulatory T cellsMucosal tolerance,Mucosal immunityAutoimmune diseaseAdoptive Treg cell transferMicrobiotaVitamin D3SCFAInflammatory bowel diseaseInmunología2412 Inmunología