Parra Gonzalo, Juan De LaCuartero Desviat, María IsabelPérez Ruiz, AlbertoGarcía Culebras, AliciaMartín Herranz, RicardoSánchez-Prieto Borja, JoséGarcía Segura, Juan ManuelLizasoaín Hernández, IgnacioMoro Sánchez, María Ángeles2024-01-222024-01-222018De La Parra, Juan, et al. «AhR Deletion Promotes Aberrant Morphogenesis and Synaptic Activity of Adult-Generated Granule Neurons and Impairs Hippocampus-Dependent Memory». Eneuro, vol. 5, n.o 4, julio de 2018, p. ENEURO.0370-17.2018. https://doi.org/10.1523/ENEURO.0370-17.2018.2373-282210.1523/eneuro.0370-17.2018https://hdl.handle.net/20.500.14352/94497Newborn granule cells are continuously produced in the subgranular zone of dentate gyrus throughout life. Once these cells mature, they integrate into pre-existing circuits modulating hippocampus-dependent memory. Subsequently, mechanisms controlling generation and maturation of newborn cells are essential for proper hippocampal function. Therefore, we have studied the role of aryl hydrocarbon receptor (AhR), a ligand-activated bHLH-PAS transcription factor, in hippocampus-dependent memory and granule neuronal morphology and function using genetic loss-of-function approaches based on constitutive and inducible-nestin AhR–/– mice. The results presented here show that the impaired hippocampus-dependent memory in AhR absence is not due to its effects on neurogenesis but to aberrant dendritic arborization and an increased spine density, albeit with a lower number of mature mushrooms spines in newborn granule cells, a finding that is associated with an immature electrophysiological phenotype. Together, our data strongly suggest that AhR plays a pivotal role in the regulation of hippocampal function, by controlling hippocampal granule neuron morphology and synaptic maturation.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal articlehttps://doi.org/10.1523/ENEURO.0370-17.2018open access612.82Aryl hydrocarbon receptorDendrite arborizationHippocampal memoryNewborn granule cellsNeurociencias (Biológicas)2410 Biología Humana