Forté, EmmanuelMarín Gabriel, José CarlosCuadrado Tiemblo, CristinaPioche, Mathieu2026-01-212026-01-212020-03-02Forté, E., Petit, B., Walter, T., Lépilliez, V., Vanbiervliet, G., Rostain, F., Barsic, N., Albeniz, E., Gete, G. G., Gabriel, J. C. M., Cuadrado-Tiemblo, C., Ratone, J. P., Jacques, J., Wallenhorst, T., Subtil, F., Albouys, J., Giovannini, M., Chaussade, S., Landel, V., Ponchon, T., … Pioche, M. (2020). Risk of neoplastic change in large gastric hyperplastic polyps and recurrence after endoscopic resection. Endoscopy, 52(6), 444–453. https://doi.org/10.1055/a-1117-31660013-726X10.1055/a-1117-3166https://hdl.handle.net/20.500.14352/130714Background: Gastric hyperplastic polyps (GHPs) have a risk of neoplastic transformation reaching 5 %. Current endoscopic resection techniques appear suboptimal with a high risk of local recurrence. This study assessed the outcomes of endoscopic resection for GHPs and identified risk factors for recurrence and neoplastic transformation. Methods: This retrospective, multicenter, European study included adult patients with at least one GHP ≥ 10 mm who underwent endoscopic resection and at least one follow-up endoscopy. Patients with recurrent GHPs or hereditary gastric polyposis were excluded. All data were retrieved from the endoscopy, pathology, and hospitalization reports. Results: From June 2007 to August 2018, 145 GHPs in 108 patients were included. Recurrence after endoscopic resection was 51.0 % (74 /145) in 55 patients. R0 resection or en bloc resection did not impact the risk of polyp recurrence. In multivariate analysis, cirrhosis was the only risk factor for recurrence (odds ratio [OR] 4.82, 95 % confidence interval [CI] 1.33 - 17.46; P = 0.02). Overall, 15 GHPs (10.4 %) showed neoplastic transformation, with size > 25 mm (OR 10.24, 95 %CI 2.71 - 38.69; P < 0.001) and presence of intestinal metaplasia (OR 5.93, 95 %CI 1.56 - 22.47; P = 0.01) being associated with an increased risk of neoplastic transformation in multivariate analysis. Conclusions: Results confirmed the risk of recurrence and neoplastic transformation of large GHPs. The risk of neoplastic change was significantly increased for lesions > 25 mm, with a risk of high grade dysplasia appearing in polyps ≥ 50 mm. The risk of recurrence was high, particularly in cirrhosis patients, and long-term follow-up is recommended in such patients.engjournal articlehttps://doi.org/10.1055/a-1117-3166https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1117-3166restricted access616-072.1Ciencias Biomédicas32 Ciencias Médicas