Gisbert Garzarán, MiguelLozano Borregón, DanielVallet Regí, María Dulce NombreManzano García, Miguel2023-06-172023-06-172016-12-071 O. C. Farokhzad and R. Langer, ACS Nano, 2009, 3, 16–20. 2 J. D. Byrne, T. Betancourt and L. Brannon-Peppas, Adv. Drug Deliv. Rev., 2008, 60, 1615–1626. 3 S. Mura, J. Nicolas and P. Couvreur, Nat. Mater., 2013, 12, 991–1003. 4 R. Misra, S. Acharya and S. K. Sahoo, Drug Discov. Today, 2010, 15, 842–850. 5 A. Baeza, M. Manzano, M. Colilla and M. Vallet-regí, Biomater. Sci., 2016, 4, 803–813. 6 F. Tang, L. Li and D. Chen, Adv. Mater., 2012, 24, 1504–1534. 7 Z. Li, J. C. Barnes, A. Bosoy, J. F. Stoddart and J. I. Zink, Chem. Soc. Rev., 2012, 41, 2590. 8 C. E. Ashley, E. C. Carnes, G. K. Phillips, D. Padilla, P. N. Durfee, P. a Brown, T. N. Hanna, J. Liu, B. Phillips, M. B. Carter, N. J. Carroll, X. Jiang, D. R. Dunphy, C. L. Willman, D. N. Petsev, D. G. Evans, A. N. Parikh, B. Chackerian, W. Wharton, D. S. Peabody and C. J. Brinker, Nat. Mater., 2011, 10, 389–397. 9 I. I. Slowing, J. L. Vivero-Escoto, B. G. Trewyn and V. S.-Y. Lin, J. Mater. Chem., 2010, 20, 7924–7937. 10 M. Manzano and M. Vallet-Regí, J. Mater. Chem., 2010, 20, 5593. 11 B. G. Trewyn, I. I. Slowing, S. Giri, H. Chen and V. S. Lin, Acc. Chem. Res., 2007, 40, 846–853. 12 J. L. Vivero-Escoto, I. I. Slowing, B. G. Trewyn and V. S.-Y. Lin, Small, 2010, 6, 1952–1967. 13 C. Argyo, V. Weiss, C. Bräuchle and T. Bein, Chem. Mater., 2014, 26, 435– 451. 14 Y. Zhang, Z. Zhi, T. Jiang, J. Zhang, Z. Wang and S. Wang, J. Control. Release, 2010, 145, 257–263. 15 A. Baeza, M. Colilla and M. Vallet-Regí, Expert Opin. Drug Deliv., 2015, 12, 319–337. 16 T. Kolter and K. Sandhoff, FEBS Lett., 2010, 584, 1700–1712. 17 Z. Li, H. Li, L. Liu, X. You, C. Zhang and Y. Wang, RSC Adv., 2015, 5, 77097– 77105. 18 Y. Yan, J. Fu, X. Liu, T. Wang and X. Lu, RSC Adv., 2015, 5, 30640–30646. 19 A. Sagi, R. Weinstain, N. Karton and D. Shabat, J. Am. Chem. Soc., 2008, 8, 5434–5435. 20 W. Wang and C. Alexander, Angew. Chemie - Int. Ed., 2008, 47, 7804–7806. 21 S. Gnaim and D. Shabat, Acc. Chem. Res., 2014, 47, 2970–2984. 22 R. A. McBride and E. R. Gillies, Macromolecules, 2013, 46, 5157–5166. 23 A. Baeza, E. Guisasola, A. Torres-Pardo, J. M. González-Calbet, G. J. Melen, M. Ramirez and M. Vallet-Regí, Adv. Funct. Mater., 2014, 24, 4625–4633. 24 A. S. Timin, A. R. Muslimov, K. V. Lepik, N. N. Saprykina, V. S. Sergeev, B. V. Afanasyev, A. D. Vilesov and G. B. Sukhorukov, J. Mater. Chem. B, 2016, 18, 33–37. 25 A. S. Timin, H. Gao, D. V. Voronin, D. A. Gorin and G. B. Sukhorukov, Adv. Mater. Interfaces, 2016. 26 B. Gonzalez, M. Colilla, C. L. de Laorden and M. Vallet-Regi, J. Mater. Chem., 2009, 19, 9012–9024. 27 A. Verma and F. Stellacci, Small, 2010, 6, 12–21. 28 K. Ulbrich, K. Holá, V. Šubr, A. Bakandritsos, J. Tuček and R. Zbořil, Chem. Rev., 2016, 116, 5338–5431.2046-206910.1039/C6RA26771Hhttps://hdl.handle.net/20.500.14352/17591RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)A novel pH-sensitive nanocarrier based on mesoporous silica nanoparticles with self-immolative polymers blocking the pore openings is presented. Triggered release by acid pH is demonstrated, together with their in vitro biocompatibility and effective cell internalisation, which makes this new material a promising candidate for future applications in cancer treatment.engAtribución 3.0 Españajournal articlehttp://www.rsc.org/open access66546615.46BiomaterialsPolymersMateriales biomédicosPolímerosMaterialesQuímica inorgánica (Química)3312 Tecnología de Materiales2303 Química Inorgánica