Carracedo Añón, Julia MaríaAlique, MatildeRamírez Carracedo, RafaelBodega, GuillermoRamírez, Rafael2025-11-072025-11-072019-08-01Carracedo, J., Alique, M., Ramírez-Carracedo, R., Bodega, G., & Ramírez, R. (2019). [Rev. of Tendothelial extracellular vesicles produced by senescent cells: Pathophysiological role in the cardiovascular disease associated with all types of diabetes mellitus]. Current Vascular Pharmacology, 17(5), 447-454. https://doi.org/10.2174/15701611166661808201157261570-161110.2174/1570161116666180820115726https://hdl.handle.net/20.500.14352/125892This work was supported by Plan Nacional Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII) Fondos Feder European Grants (PI14/00806, PI17/01029), Junta de Andalucía Grants (P12-CTS-7352), Santander-UCM Grants (PR41/17-20964), UAH-GP2018-4. Red de Investigación Renal (REDinREN; RD16/0009/0034). Rafael Ramírez-Carracedo is a fellow of the program FPI (Formación de Personal Investigador) from Universidad Francisco de Vitoria, Madrid, Spain.Endothelial senescence-associated with aging or induced prematurely in pathological situations, such as diabetes, is a first step in the development of Cardiovascular Disease (CVDs) and particularly inflammatory cardiovascular diseases. The main mechanism that links endothelial senescence and the progression of CVDs is the production of altered Extracellular Vesicles (EVs) by senescent endothelial cells among them, Microvesicles (MVs). MVs are recognized as intercellular signaling elements that play a key role in regulating tissue homeostasis. However, MVs produced by damage cell conveyed epigenetic signals, mainly involving microRNAs, which induce many of the injured responses in other vascular cells leading to the development of CVDs. Many studies strongly support that the quantification and characterization of the MVs released by senescent endothelial cells may be useful diagnostic tools in patients with CVDs, as well as a future therapeutic target for these diseases. In this review, we summarize the current knowledge linking senescence-associated MVs to the development of CVDs and discuss the roles of these MVs, in particular, in diabetic-associated increases the risk of CVDs.engjournal article1875-6212https://doi.org/10.2174/1570161116666180820115726https://www.eurekaselect.com/article/92490restricted access612.1612.17616.12616.12-005616.4616.379-008.64Cardiovascular diseasesDiabetesEndothelial senescenceEpigenetic signalsExtracellular vesiclesMicrovesiclesPhysiopathological mechanismsCardiologíaSistema cardiovascularFisiologíaEndocrinología3205.01 Cardiología3207.04 Patología Cardiovascular2411.03 Fisiología Cardiovascular3205.02 Endocrinología