Gutiérrez Estévez, ManuelCicuéndez Maroto, MónicaCrespo, JuliánSerrano-López, JuanaColilla Nieto, MontserratFernández-Acevedo, ClaudioOroz-Mateo, TamaraRada-Leza, AmaiaGonzález Ortiz, BlancaIzquierdo Barba, IsabelVallet Regí, María Dulce Nombre2023-09-272023-09-272023-07-040021-979710.1016/j.jcis.2023.07.009https://hdl.handle.net/20.500.14352/87969Acuerdo transformativoDespite the large number of synthesis methodologies described for superparamagnetic iron oxide nanoparticles (SPIONs), the search for their large-scale production for their widespread use in biomedical applications remains a mayor challenge. Flame Spray Pyrolysis (FSP) could be the solution to solve this limitation, since it allows the fabrication of metal oxide nanoparticles with high production yield and low manufacture costs. However, to our knowledge, to date such fabrication method has not been upgraded for biomedical purposes. Herein, SPIONsengAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://www.sciencedirect.com/science/article/pii/S0021979723012584?via%3Dihubopen access615.46546Superparamagnetic iron oxide nanoparticlesFlame spray pyrolysisLarge-scale productionBiocompatibilityHemocompatibilityHuman mesenchymal stem cellsBiomedical applicationsQuímica inorgánica (Farmacia)Materiales2303 Química Inorgánica