Luque, JordiTorres, María IsabelAumente, María DoloresMarín, JoséGarcía-Jurado, GemaGonzález, RafaelPascual, DomingoGuerra Pérez, NataliaLópez-Rubio, FernandoAlvarez-López, RocíoArizón, JoséPeña, José2024-02-012024-02-012006Luque, J., et al. «Soluble HLA-G in Heart Transplantation: Their Relationship to Rejection Episodes and Immunosuppressive Therapy». Human Immunology, vol. 67, n.o 4-5, abril de 2006, pp. 257-63. https://doi.org/10.1016/j.humimm.2006.02.034.0198-885910.1016/j.humimm.2006.02.034https://hdl.handle.net/20.500.14352/97737The aims of this study were to quantify the level of soluble HLA-G in heart transplant patients, to determine the relationship between the sHLA-G levels and the appearance of acute rejection episodes, and to identify the influence of immunosuppressive therapy on sHLA-G levels. Analysis of sHLA-G, measured by enzyme-linked immunosorbent assay in the transplant patients, revealed the existence of two similarly sized groups of patients. One group displayed a significant increase (p < 0.001) in sHLA-G during the first month after transplantation while the other group maintained low levels of the molecule (0–30 ng/ml) throughout the study. The latter group displayed a high incidence of recurrent severe rejection. A significant increase (p < 0.01) in sHLA-G 2 hours after administration of immunosuppressive treatment (mycophenolate mofetil, cyclosporine A/FK506, corticoids) was found. These results suggest that sHLA-G participates in the induction of certain levels of immunological tolerance in these recipients.engAttribution-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nd/4.0/journal article1879-1166https://doi.org/10.1016/j.humimm.2006.02.034https://www.sciencedirect.com/science/article/pii/S0198885906000218?via%3Dihubrestricted accessBiología2412 Inmunología