Sánchez Conde, MatildeAlba Rubio, ClaudioCastro Navarro, IrmaDronda, FernandoRamírez, MargaritaArroyo Rodríguez, RebecaMoreno Guillén, SantiagoRodríguez Gómez, Juan MiguelBrañas Baztán, Fátima Beatriz2024-05-292024-05-292023-08-19Sánchez-Conde, M.; Alba, C.; Castro, I.; Dronda, F.; Ramírez, M.; Arroyo, R.; Moreno, S.; Rodríguez, J.M.; Brañas, F. Comparison of the Fecal Bacteriome of HIV-Positive and HIV-Negative Older Adults. Biomedicines 2023, 11, 2305. https://doi.org/10.3390/ biomedicines1108230510.3390/biomedicines11082305https://hdl.handle.net/20.500.14352/1045452023 Descuento MDPIHIV infection is considered a scenario of accelerated aging. Previous studies have suggested a link between aging, frailty, and gut dysbiosis, but there is a knowledge gap regarding the HIV population. Our objective was to compare the fecal bacteriome of older people with HIV (PWH) and non-HIV controls, and to assess potential links between gut dysbiosis and frailty. A total of 36 fecal samples (24 from PWH and 12 from non-HIV controls) were submitted to a metataxonomic analysis targeting the V3–V4 hypervariable region of the 16S rRNA gene. High-quality reads were assembled and classified into operational taxonomic units. Alpha diversity, assessed using the Shannon index, was higher in the control group than in the HIV group (p < 0.05). The relative abundance of the genus Blautia was higher in the HIV group (p < 0.001). The presence of Blautia was also higher in PWH with depression (p = 0.004), whereas the opposite was observed for the genus Bifidobacterium (p = 0.004). Our study shows shifts in the composition of the PWH bacteriome when compared to that of healthy controls. To our knowledge, this is the first study suggesting a potential link between depression and gut dysbiosis in the HIV population.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article2227-9059https://doi.org/10.3390/biomedicines1108230537626801open access616.9Gut microbiomeHIVAgingFrailtyDysbiosisDepressionMedicina32 Ciencias Médicas