Blizinsky, Katherine D.Diaz-Castro, BlancaForrest, Marc P.Schürmann,, BrittaBach, Anthony P.Martín De Saavedra Álvarez De Uribarri, María DoloresWang, LeiCsernansky, John G.Duan, JubaoPenzes, Peter2024-01-162024-01-162016Blizinsky KD, Diaz-Castro B, Forrest MP, Schürmann B, Bach AP, Martin-de-Saavedra MD, et al. Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub. Proc Natl Acad Sci USA 2016;113:8520–5. https://doi.org/10.1073/pnas.1607014113.0027-842410.1073/pnas.1607014113https://hdl.handle.net/20.500.14352/93463The architecture of neuronal dendritic trees is crucial for brain connectivity, whereas dendritic abnormalities are associated with psychiatric disorders. Rare copy number variations (CNVs) are a category of mutations often associated with schizophrenia, autism, and other mental disorders. However, the genetic complexity of CNV disorders poses a serious challenge for the identification of experimentally approachable mechanisms. Here we used network analysis to identify the most topologically important hub in protein–protein interaction networks within such a CNV, and in broader gene networks of psychiatric CNVs. We then show that pharmacological targeting of this node reverses dendritic alterations in a neuronal model of this CNV, outlining a strategy for the analysis and reversal of cellular phenotypes in CNV-related psychiatric disorders.engjournal article1091-6490https://doi.org/10.1073/pnas.1607014113https://www.pnas.org/doi/full/10.1073/pnas.1607014113open access611.8Ciencias Biomédicas24 Ciencias de la Vida