Orue-Echebarria, MaitaneVaquero Martín, Francisco JavierLisbona, CristinaLozano, PabloSteiner, MiguelMorales, ÁlvaroLópez Baena, José ÁngelLaso, JuanHernández, InmaculadaOlmedilla, LuisGarcía Sabrido, José LuisPeligros Gómez, María IsabelSola Vendrell, EmmaFernández Carballal, CarlosVara Ameigeiras, Elena MaríaAsencio Pascual, José Manuel2024-02-082024-02-082019Maitane I. Orue-Echebarria, Javier Vaquero, Cristina J. Lisbona, Pablo Lozano, Miguel A. Steiner, Álvaro Morales, José Á. López-Baena, Juan Laso, Inmaculada Hernández, Luis Olmedilla, José L. García Sabrido, Isabel Peligros, Emma Sola, Carlos Carballal, Elena Vara, J.M. Asencio, Comprehensive Characterization of a Porcine Model of The “Small-for-Flow” Syndrome, Journal of Gastrointestinal Surgery, Volume 23, Issue 11, 2019, Pages 2174-2183,1091-255X10.1007/s11605-019-04130-2https://hdl.handle.net/20.500.14352/100471Methods We performed subtotal (90%) hepatectomies in 10 female MiniPigs using a simplified transection technique with a tourniquet. Blood tests, hepatic and systemic hemodynamics, and hepatic function and histology were assessed before (Bas), 15 min (t-15 min) and 24 h (t-24 h) after the operation. Some pigs underwent computed tomography (CT) scans for hepatic volumetry (n = 4) and intracranial pressure (ICP) monitoring (n = 3). Postoperative care was performed in an intensive care unit environment. Results All hepatectomies were successfully performed, and hepatic volumetry confirmed liver remnant volumes of 9.2% [6.2–11.2]. The hepatectomy resulted in characteristic hepatic hemodynamic alterations, including portal hyperperfusion, relative decrease of hepatic arterial blood flow, and increased portal pressure (PP) and portal-systemic pressure gradient. The model reproduced major diagnostic features including the development of cholestasis, coagulopathy, encephalopathy with increased ICP, ascites, and renal failure, hyperdynamic circulation, and hyperlactatemia. Two animals (20%) died before t-24 h. Histological liver damage was observed at t-15 min and at t-24 h. The degree of histological damage at t-24 h correlated with intraoperative PP (r = 0.689, p = 0.028), hepatic arterial blood flow (r = 0.655, p = 0.040), and hepatic arterial pulsatility index (r = 0.724, p = 0.066). All animals with intraoperative PP > 20 mmHg presented liver damage at t-24 h. Conclusion The present 90% hepatectomy porcine experimental model is a feasible and reproducible model for investigating the “Small-for-Flow” syndrome.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://doi.org/10.1007/s11605-019-04130-230734180https://pubmed.ncbi.nlm.nih.gov/30734180/restricted access61Small-for-SizeHepatectomyPigSmall-For-FlowPosthepatectomy liver failureCirugía3213 Cirugía