Wu, DanDurán Sampedro, GonzaloFitzgerald, SheilaGarre, MassimilianoO’Shea, Donal F.2025-01-162025-01-162023Chem. Commun., 2023,59, 1951-19542050-5620http://dx.doi.org/10.1039/D2CC06461Hhttps://hdl.handle.net/20.500.14352/114683Sequential azide/diyne cycloadditions proved highly effective for the macrocyclization of a bis-azido aza-dipyrrin. Macrocyclic aza-dipyrrin could be produced in 30 min at rt in water with changes in fluorescence intensity and lifetimes measurable upon reaction. Live cell microscopy showed that aza-dipyrrins were suitable for confocal and STED super-resolution imaging and a bioorthogonal response to macrocyclization could be detected in cellular compartments. These results will encourage a broader examination of the sensing and imaging uses of aza-dipyrrins.engjournal articlehttps://pubs.rsc.org/en/content/articlelanding/2023/cc/d2cc06461hopen access547AzaBODIPYCell imagingQuímica orgánica (Química)2306 Química Orgánica