Cañete Ruiz, ÁngelArribas Anta, JuliaÁlvarez-Nava Torrego, TeresaPiedracoba Cadahia, CarlosRodríguez Carrasco, Martade la Cruz Esteban, David RafaelRomero Romero, Estebandel Pozo García, Andrés JoséDíaz Tasende, José BenjamínMarín Gabriel, José Carlos2026-01-192026-01-192019Cañete Ruiz Á, Arribas Anta J, Alvarez-Nava Torrego T, Piedracoba-Cadahia C, Rodríguez Carrasco M, Rafael de la Cruz Esteban D, Romero Romero E, Rodríguez Muñoz S, Del Pozo-García AJ, Díaz-Tasende J, Marín-Gabriel JC. Endoscopic submucosal dissection for gastric epithelial lesions: long-term results in a Spanish cohort. Rev Esp Enferm Dig. 2020 Mar;112(3):189-194. doi: 10.17235/reed.2020.6239/2019. PMID: 32022570.2340-416710.17235/reed.2020.6239/2019https://hdl.handle.net/20.500.14352/130564Introduction: endoscopic submucosal dissection for gastric lesions (ESD-G) is a technique that allows en-bloc resection of early gastric tumors, with a cure rate similar to that of surgery but lower morbidity and mortality rates. Objective: to assess total survival, disease-free survival and relapse rate during the course of disease in a Spanish cohort of patients undergoing ESD-G. Material and methods: this was a prospective observational study of patients undergoing ESD-G from 2008 to 2015, with a follow-up ranging from six to 60 months. Recurrence at five years was analyzed using Kaplan-Meier curves and the results were compared according to several factors using the log-rank test. These included en-bloc versus piecemeal resection and R0 curative resection versus resection with affected lateral margins (LM+). Results: a total of 35 patients undergoing ESD-G were assessed, with a median follow-up of 33.62 months. Four relapses were identified (11.4%) during this period, of which three were managed with repeat ESD-G. A histological specimen with LM+ was associated with a higher local relapse rate during follow-up (p = 0.06). Piecemeal resections had a higher relapse risk, although no statistically significant differences were identified (p = 0.49). No deaths from gastric cancer occurred and no gastrectomies due to persistent disease were performed during this period. The overall survival rate in our series was 94.3%. Conclusions: ESD-G in our setting provides high long-term cure rates, while avoiding surgery. These results are similar to those reported by the European series and remain far removed from the cure and relapse rates obtained in Asian cohorts. Local relapse cases may be monitored with endoscopy.engjournal articlehttps://doi.org/10.17235/reed.2020.6239/201932022570https://www.reed.es/open access616.3Gastric cancer; Endoscopic submucosal dissection; Survival; Gastric carcinoma; Long-term outcome.Ciencias Biomédicas32 Ciencias Médicas