Indium-mediated preparation of bis(α-hydroxyallenes) or α,α´-dihydroxyallenynes and further gold-catalyzed cyclizations

San Martín, DanielMartínez Del Campo, TeresaGamarra, L.Cerrón, E.Cembellín Santos, SaraYanai, H.Almendros, P.2025-07-302025-07-302024-09-17Martínez del Campo, T.*; San Martín, D.; Gamarra, L.; Cerrón, E.; Cembellín, S.; Yanai, H.; Almendros, P.* J. Org. Chem. 2024, 89, 14228-1423210.1021/acs.joc.4c01648https://hdl.handle.net/20.500.14352/122888We present the regio- and diastereoselective Barbier-type allenylation reaction of glyoxals mediated by indium to furnish highly valuable syn-bis(α-hydroxyallenes) and syn-α,α′-dihydroxyallenynes. The gold-catalyzed controlled cyclization of these unsaturated diols enables the divergent preparation of three types of oxacycles.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Indium-mediated preparation of bis(α-hydroxyallenes) or α,α´-dihydroxyallenynes and further gold-catalyzed cyclizationsjournal article10.1021/acs.joc.4c01648open access547α-hydroxyallenesoxacyclesQuímica orgánica (Química)2306 Química Orgánica