Pacheco Quito, Edisson MauricioBedoya Del Olmo, Luis MiguelRubio, JuanTamayo, AitanaRuiz Caro, RobertoVeiga Ochoa, María Dolores2023-06-222023-06-222022-09-270378-517310.1016/j.ijpharm.2022.122239https://hdl.handle.net/20.500.14352/72119CRUE-CSIC (Acuerdos Transformativos 2022)Genital herpes is one of the most common sexually transmitted infections worldwide. It mainly affects women, as the rate of sexual transmission from male-to-female is higher than from female-to-male. The application of vaginal antivirals drugs could reduce the prevalence of genital herpes and prevent future infections. Layer-bylayer vaginal films were prepared by the solvent evaporation method using iota-carrageenan, hydroxypropyl methylcellulose and the polymethacrylates Eudragit® RS PO and Eudragit® S100, for the controlled release of acyclovir. The films were characterized by texture analysis and Raman spectroscopy. Swelling, mucoadhesion, and drug release studies were conducted in simulated vaginal fluid. The results show that Layer-by-Layer films exhibited adequate mechanical properties. The structuring of the layer-by-layer films allowed the controlled release of acyclovir and produced a prolonged mucoadhesion residence time of up to 192 h. The films formed in layer 2 by the combination of Eudragit® RS PO and S100 showed a controlled release of acyclovir for eight days, and adequate mechanical properties. These promising formulations for the prevention of genital herpes deserve further evaluation.engAtribución-NoComercial-SinDerivadas 3.0 Españahttps://creativecommons.org/licenses/by-nc-nd/3.0/es/journal articlehttps://doi.org/10.1016/j.ijpharm.2022.122239open accessGenital herpesAcyclovir controlled releaseMarine polymersLayer-by-layer filmIota-carrageenanHydroxypropyl methylcelluloseFarmacología (Farmacia)3209 Farmacología