Muñoz Navarro, CarolinaSánchez Beltrán, María Del CarmenArriagada Vargas, CarolinaBatalla Vázquez, PilarDiniz Freitas, MárcioLimeres Posse, JacoboDiz Dios, PedroGarcía Mato, Eliane2024-07-172024-07-172022-12-04Muñoz Navarro, C.; del Carmen Sánchez Beltrán, M.; Arriagada Vargas, C.; Batalla Vázquez, P.; Diniz Freitas, M.; Limeres Posse, J.; Diz Dios, P.; García Mato, E. Analysis of the Oral Microbiome in a Patient with Cardiofaciocutaneous Syndrome and Severe Periodontal Disease: Impact of Systemic Antibiotic Therapy. Antibiotics 2022, 11, 1754. https://doi.org/10.3390/antibiotics111217542079-638210.3390/ antibiotics11121754https://hdl.handle.net/20.500.14352/106778An 8-year-old girl diagnosed with cardiofaciocutaneous syndrome presented to our department with gingival pain, inflammation, and bleeding. Her medical history included hypoplasia of the corpus callosum, intellectual disability, trichothiodystrophy, global developmental delay, myopia, laryngomalacia, hypothyroidism, and osteoporosis. A diagnosis was reached of “periodontitis as a direct manifestation of systemic diseases”. During 9 years of follow-up, there were exacerbation episodes with spontaneous gum bleeding, ulcers in the interdental papilla, tooth mobility, and progressive tooth loss. Some of these exacerbation episodes resolved clinically with the administration of amoxicillin and metronidazole. We therefore proposed an oral microbiome study (subgingival and saliva samples) before and after antibiotic therapy. The most abundant genera at the subgingival level before administering antibiotics were Prevotella, Streptococcus, Fusobacterium, Leptotrichia, and Aggregatibacter. Of the 94 genera sequenced, 57 were less abundant in the post-treatment state than at baseline, particularly certain Gram-negative periodontal pathogens such as Porphyromonas, Treponema, Aggregatibacter, Fusobacterium, and Campylobacter. In contrast, other genera related to oral health, such as Haemophilus, Granulicatella, and Abiotrophia, showed an increase after administering the antibiotic. In conclusion, periodontitis exacerbations as a direct manifestation of systemic disease can occasionally be controlled exclusively with systemic antibiotics, without the need for performing mechanical periodontal therapy. This clinical recovery is correlated to substantial changes in the oral microbiome, which lead to the recovery of eubiosis of the microbiota.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal articlehttps://doi.org/10.3390/antibiotics11121754open access616.314.17-008.1cardiofaciocutaneous syndromeperiodontitisantibioticsmicrobiomeCiencias Biomédicas32 Ciencias Médicas