Martinez Maldonado, AndresJurado Barba, RosaSion, Ana Mª AlexandraDominguez Centeno, IsabelCastillo Parra, GabrielaPrieto Montalvo, Julio IgnacioRubio Valladolid, Gabriel2026-03-052026-03-052020-08Martínez-Maldonado, A., Jurado-Barba, R., Sion, A., Domínguez-Centeno, I., Castillo-Parra, G., Prieto-Montalvo, J., & Rubio, G. (2020). Brain functional connectivity after cognitive-bias modification and behavioral changes in abstinent alcohol-use disorder patients. International Journal of Psychophysiology, 154, 46-58. https://doi.org/10.1016/j.ijpsycho.2019.10.00410.1016/j.ijpsycho.2019.10.004https://hdl.handle.net/20.500.14352/133823The use of the cognitive-bias modification (CBM) method has emerged as a therapeutic complement in the treatment of alcoholism, producing changes at behavioral and brain level. Nevertheless, the impact of the CBM procedure could be improved by the memory retrieval-extinction process (REP). Different studies have demonstrated that the retrieval of drug memories before extinction training later reduced the reinstatement of drug-seeking behavior. The main aim of this work was to study the effect of the CBM procedure itself, as well as in combination with the activation of alcohol-related memories, on the brain oscillatory activity of abstinent patients with alcohol-use disorder. The study sample comprised 33 patients divided into three groups: A-CBM (alcohol-related memory activation + CBM), N-CBM (neutral memory activation + CBM) and N-INT (no-intervention) groups. A resting-state EEG was obtained before and after each protocol, along with the assessment of the automatic action tendencies. A-CBM group showed a general alpha synchronization increase after the protocol, while the other groups did not show any significant change. Besides, A-CBM group showed significant intra and inter-group differences in the automatic action tendencies after the protocol, reflected in higher avoidance bias toward appetitive, aversive and without context alcohol-related stimuli. The alpha phase synchronization increase could be the neural manifestation of the conditioning produced between the alcohol-related stimuli and the automatic avoidance response. Moreover, the activation of the alcohol-related memories favors this conditioning with those alcohol-related stimuli associated with the activated memories, because it increases their threat level for the abstinence maintenance.engjournal articlehttps://doi.org/10.1016/j.ijpsycho.2019.10.00431654697restricted accessBrain connectivityBrain oscillationsSubstance use disorderBrain trainingImplicit attitudesMemory and learning measuresPsicología (Psicología)Neuropsicología6106.10 Psicología Fisiológica