Puell Marín, María CintaHurtado Ceña, Francisco JavierPérez Carrasco, María JesúsContreras Martín, Inés2023-06-172023-06-17© 2020 SAG2020-11-05Puell Marín, M. C., Hurtado Ceña, F. J., Pérez Carrasco, M. J., Contreras Martín, I. «Association between Central Retinal Thickness and Low Luminance Visual Acuity in Early Age-Related Macular Degeneration». European Journal of Ophthalmology, vol. 31, n.o 5, septiembre de 2021, pp. 2467-73. DOI.org (Crossref), https://doi.org/10.1177/1120672120968740.1120-672110.1177/1120672120968740https://hdl.handle.net/20.500.14352/7513Purpose/Aim: To examine whether central retinal thickness (CRT) is related to mesopic visual acuity (VA) and low luminance deficit (LLD, difference between photopic and mesopic VA) in eyes with early and intermediate age-related macular degeneration (AMD). Materials and Methods: In a cross-sectional study, 50 pseudophakic subjects older than 63 years were divided into three groups (no AMD, early AMD and intermediate AMD). Spectral domain optical coherence tomography (SD-OCT) was used to measure CRT in the 1 mm-central-area. Best-corrected distance VA was measured under photopic or mesopic luminance conditions and LLD calculated. Subjects were stratified by VA impairment to compare CRTs across these groups. Relationships were examined by stepwise multiple linear regression. Results: No significant differences in mean CRT, photopic and mesopic VA or LLD were detected between the groups no AMD, early AMD and intermediate AMD. However, mean CRTs were 20 microns and 18 microns thicker in the eyes with impaired mesopic VA (> 0.3 logMAR) and impaired LLD (⩾ 0.3 logMAR) compared to the eyes with non-impaired VA or LLD respectively (both p < 0.01). CRT and mesopic pupil size were independent predictors of mesopic VA (p = 0.001). CRT emerged as the only independent predictor of LLD (p = 0.004). Conclusions: Increased CRT was linked to worse retinal function when measured under mesopic conditions in eyes without AMD and eyes with early to intermediate AMD. SD-OCT imaging combined with VA measurements under low luminance conditions could be a useful tool to detect early AMD.engjournal articlehttps://doi.org/10.1177%2F1120672120968740https://journals.sagepub.com/doi/abs/10.1177/1120672120968740open access617.736-053.9617.735--003.8617.75Age-related macular degenerationCentral retinal thicknessVisual acuityMesopic visionLow luminance deficitRetinaOftalmologíaOptometría3201.09 Oftalmología2209.15 Optometría