Klionsky, Daniel J.Bravo San Pedro, José ManuelPietrocola, Federico2025-12-152025-12-152021Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, et al. Autophagy in major human diseases. EMBO journal. 2021;40(19):e1088630261-418910.15252/embj.2021108863https://hdl.handle.net/20.500.14352/128916Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article1460-2075https://doi.org/10.15252/embj.202110886334459017https://link.springer.com/article/10.15252/embj.2021108863https://pubmed.ncbi.nlm.nih.gov/34459017/open access612AgingCancerInflammationMetabolic syndromesNeurodegenerationCiencias BiomédicasFisiología32 Ciencias Médicas2411 Fisiología Humana