Castillo Romero, RafaelVallet Regí, María Dulce Nombre2023-06-162023-06-162021-06-301178-201310.2147/IJN.S273064https://hdl.handle.net/20.500.14352/4403RESEARCH ID L-2854-2014  (Rafael Castillo Romero) ORCID 0000-0003-1957-3098 (Rafael Castillo Romero) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)It is a fact that the use of antibiotics is inducing a growing resistance on bacteria. This situation is not only the consequence of a drugs’ misuse, but a direct consequence of a widespread and continuous use. Current studies suggest that this effect could be reversed by using abandoned antibiotics to which bacteria have lost their resistance, but this is only a temporary solution that in near future would lead to new resistance problems. Fortunately, current nanotechnology offers a new life for old and new antibiotics, which could have significantly different pharmacokinetics when properly delivered; enabling new routes able to bypass acquired resistances. In this contribution, we will focus on the use of porous silica nanoparticles as functional carriers for the delivery of antibiotics and biocides in combination with additional features like membrane sensitizing and heavy metal-driven metabolicdisrupting therapies as two of the most interesting combination therapiesengAtribución-NoComercial 3.0 Españahttps://creativecommons.org/licenses/by-nc/3.0/es/journal articlehttps://www.dovepress.com/international-journal-of-nanomedicine-journalhttps://www.ucm.es/valletregigroupopen accessmesoporous silicabacteriainfectioncombination therapydrug deliveryMateriales3312 Tecnología de Materiales