Lopez-Tello, JorgeJiménez Martínez, María de los ÁngelesHerrera, EmilioKrause, BernardoSferruzzi-Perri, Amanda2024-01-282024-01-2820180143-400410.1016/j.placenta.2018.10.003https://hdl.handle.net/20.500.14352/95693Supplementary data to this article can be found online at https:// doi.org/10.1016/j.placenta.2018.10.003.Intrauterine growth restriction (IUGR) is a common obstetric complication with immediate and life-long consequences for offspring health. Yet the mechanisms underlying its aetiology require elucidation. Recent work in the guinea pig shows that progressive uterine artery occlusion induced IUGR and vascular dysfunction in pups. Here we explore the extent to which uterine artery occlusion influences fetal outcomes via impacts on placental morphology. Our study demonstrates that uterine artery occlusion severely compromised both the labyrinth exchange zone (increased fibrosis and reduced vascularisation, trophoblast volume, surface area and diffusing capacity) and interlobium zone (increased apoptosis), which likely contributed to the IUGR observed.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article1532-3102https://doi.org/10.1016/j.placenta.2018.10.00330501879restricted access61IUGRGuinea pigAmeroid constrictorPlacental insufficiencyPlacental morphologyCiencias Biomédicas32 Ciencias Médicas