Garrido Novelle, MartaAli, AhmedDiéguez, CarlosBernier, MichelDe Cabo, Rafael2024-01-232024-01-232016Novelle, Marta G., et al. «Metformin: A Hopeful Promise in Aging Research». Cold Spring Harbor Perspectives in Medicine, vol. 6, n.o 3, marzo de 2016, p. a025932. https://doi.org/10.1101/cshperspect.a025932.10.1101/cshperspect.a025932https://hdl.handle.net/20.500.14352/94831This work is supported by the Intramural Research Program of the National Institute on Aging, National Institutes of Health. CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII. The funding agency had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Even though the inevitable process of aging by itself cannot be considered a disease, it is directly linked to life span and is the driving force behind all age-related diseases. It is an undisputable fact that age-associated diseases are among the leading causes of death in the world, primarily in industrialized countries. During the last several years, an intensive search of antiaging treatments has led to the discovery of a variety of drugs that promote health span and/or life extension. The biguanide compound metformin is widely used for treating people with type 2 diabetes and appears to show protection against cancer, inflammation, and age-related pathologies. Here, we summarize the recent developments about metformin use in translational aging research and discuss its role as a potential geroprotector.engjournal article2157-1422https://doi.org/10.1101/cshperspect.a025932restricted access615.2Tecnología farmaceútica2402.15 Envejecimiento Somático3209 Farmacología