Scherma, MaríaSatta, ValentinaFratta, WalterFadda, PaolaFattore, Liana2026-02-132026-02-132015Maria Scherma, Valentina Satta, Walter Fratta, Paola Fadda, Chapter 16 - The endocannabinoid system: Anorexia nervosa and binge eating disorder, Editor(s): Liana Fattore, Cannabinoids in Neurologic and Mental Disease, Academic Press, 2015, Pages 389-413, ISBN 9780124170414, https://doi.org/10.1016/B978-0-12-417041-4.00016-3.978012417041410.1016/B978-0-12-417041-4.00016-3https://hdl.handle.net/20.500.14352/132294Eating disorders (EDs) include a range of chronic and disabling related psychiatric pathologies characterized by aberrant eating patterns or weight-control behavior and distorted body image. The etiology of EDs is complex and not yet completely understood. The endocannabinoid system has been widely reported to be involved in the regulation of feeding and energy balance, and cannabinoid type-1 receptors (CB1Rs) are expressed in many brain regions that control food intake. Animal and human studies indicate that CB1R agonists possess orexigenic effects enhancing appetite and increasing the perceived reward value of food. Conversely, CB1R antagonists have been shown to inhibit food intake. Previous clinical and preclinical evidence has led us to hypothesize a link between defects in the endocannabinoid system and EDs and supports the development of drugs that modulate this system in ED-related pathologies.engbook parthttps://doi.org/10.1016/B978-0-12-417041-4.00016-3https://www.sciencedirect.com/science/chapter/edited-volume/abs/pii/B9780124170414000163metadata only accessCiencias Biomédicas32 Ciencias Médicas