Perales, MaríaValenzuela, PedroBarakat, RubénAlejo, LidiaCordero Rodríguez, Yaiza AdelaPeláez, MireiaLucía Mulas, Alejandro2024-02-052024-02-052020Perales, M., Valenzuela, P. L., Barakat, R., Brea Alejo, L., Cordero, Y., Peláez, M., & Lucia, A. (2021). Obesity can offset the cardiometabolic benefits of gestational exercise. International Journal of Obesity, 45(2), 342-347. https://doi.org/10.1038/S41366-020-00669-20307-056510.1038/s41366-020-00669-2https://hdl.handle.net/20.500.14352/99172Pregnancy exercise can prevent excessive gestational weight gain (EGWG), gestational diabetes mellitus (GDM) and hypertension (GH), but inter-individual variability has not been explored. We aimed to analyze the prevalence--and potential sociodemographic and medical predictors of--non-responsiveness to gestational exercise, and the association of non-responsiveness with adverse pregnancy outcomes. Among 688 women who completed a supervised light-to-moderate intensity exercise program (three ~1-h sessions/week including aerobic, resistance, and pelvic floor muscle training) until near-term, those who showed EGWG, GDM or GH were considered 'non-responders'. A low prevalence of non-responders was observed for GDM (3.6%) and GH (3.4%), but not for EGWG (24.2%). Pre-pregnancy obesity was the strongest predictor of non-responsiveness for GH (odds ratio 8.40 [95% confidence interval 3.10-22.78] and EGWG (5.37 [2.78-10.39]), whereas having a highest education level attenuated the risk of being non-responder for GDM (0.10 [0.02-0.49]). Non-responsiveness for EGWG was associated with a higher risk of prolonged labor length, instrumental/cesarean delivery, and macrosomia, and of lower Apgar scores. No association with negative delivery outcomes was found for GDM/GH. In summary, women with pre-pregnancy obesity might require from additional interventions beyond light-to-moderate intensity gestational exercise (e.g., diet and/or higher exercise loads) to ensure cardiometabolic benefitsengAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article1476-5497https://doi.org/10.1038/s41366-020-00669-232887923https://www.nature.com/ijo/https://produccioncientifica.ucm.es/documentos/6038da8385382a6b3d7bb265#https://pubmed.ncbi.nlm.nih.gov/32887923/https://www.scopus.com/record/display.uri?eid=2-s2.0-85090233831&origin=resultslisthttps://scholar.google.com/scholar_lookup?title=Obesity+can+offset+the+cardiometabolic+benefits+of+gestational+exercise&author=Perales%2C+M.&author=Valenzuela%2C+P.L.&author=Barakat%2C+R.&author=Alejo%2C+L.B.&author=Cordero%2C+Y.&author=Pel%C3%A1ez%2C+M.&author=Lucia%2C+A.&publication_year=2021&journal=International+Journal+of+Obesity&volume=45&issue=2&pages=342-347&doi=10.1038/S41366-020-00669-2&pmid=32887923&issn=1476-5497&hl=eshttps://pubmed.ncbi.nlm.nih.gov/32887923/restricted access796616.4613.2AdultBody Mass IndexDiabetesGestationalExerciseExercise TherapyFemaleGestational Weight GainHumansHypertensionPregnancy-InducedObesityPregnancyPregnancy OutcomePrenatal CareRandomized Controlled Trials as TopicRisk FactorsEducación física y deportivaDietética y nutrición (Medicina)EndocrinologíaGinecología y obstetricia5899 Otras Especialidades Pedagógicas3210 Medicina Preventiva