Bustamante Domínguez, RocíoGómez de Segura IACanfrán Arrabe, Susana2024-01-302024-01-302024-01-17Bustamante, R., Canfrán, S., & de Segura, I. G. (2024). Clinical evaluation of the sedative, antinociceptive and cardiorespiratory effects of intranasal dexmedetomidine combined with methadone in healthy dogs. The Veterinary Journal, 106065.1090-0233https://doi.org/10.1016/j.tvjl.2024.106065https://hdl.handle.net/20.500.14352/96656In this prospective, randomised, blinded clinical study, we compared the sedative, antinociceptive and cardiorespiratory effects of intranasal (IN) dexmedetomidine at 5 μg/kg (diluted with 0.03 mL/kg NaCl 0.9%, DEX) with or without methadone (0.3 mg/kg; DEXMET), through a mucosal atomization device to one nostril in twenty healthy client-owned dogs. At 5-min intervals over 45 min, sedation score, onset, cardiopulmonary variables, mechanical nociceptive thresholds (MNTs) were assessed, also ease of administration, adverse effects, and response to IV catheterization. Statistical analysis employed t-test, the Mann-Whitney U, repeated measures ANOVA and Chi-square tests as appropriate (P < 0.05). Higher sedation ocurred in DEXMET (7 [5–10]) compared to DEX (5 [2–7]) from 15 to 30 min (P < 0.01, median [interquartile range]). Heart rate was lower in DEXMET (P < 0.01; 65% reduction vs. 41% in DEX, P = 0.001). The MNTs were higher in DEXMET than DEX from 15 to 45 min (P < 0.01), peaking at T30 (17.1 ± 3.8, DEXMET and 8.5 ± 5.4 N, DEX). No differences were observed in mean arterial blood pressure and respiratory rate. Intranasal administration was considered easy for 8 dogs per group. Reverse sneezing (8 dogs; P < 0.001), sialorrhea and retching (4 and 2 dogs, respectively) occurred in DEXMET. Response to catheterisation was lower in DEXMET than DEX (P = 0.039; 2 and 7 dogs, respectively). In conclusion, intranasal methadone (0.3 mg/kg) increased the sedative and antinociceptive effects produced by dexmedetomidine (5 μg/kg) in healthy dogs and resulted in lower heart rate.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article1532-2971https://www.sciencedirect.com/science/article/pii/S1090023324000042?via%3Dihub38228282https://pubmed.ncbi.nlm.nih.gov/38228282/open accessDexmedetomidineDogIntranasalSedationMethadoneCiencias BiomédicasVeterinaria32 Ciencias Médicas