Martínez De Toda Cabeza, IreneGarrido, AntonioVida, CarmenGomez-Cabrera, Mari CarmenViñas Pinedo, María JoséFuente Del Rey, María Mónica De La2024-01-102024-01-102018Irene Martinez de Toda, Antonio Garrido, Carmen Vida, Mari Carmen Gomez-Cabrera, Jose Viña, Monica De la Fuente, Frailty Quantified by the “Valencia Score” as a Potential Predictor of Lifespan in Mice, The Journals of Gerontology: Series A, Volume 73, Issue 10, October 2018, Pages 1323–1329, https://doi.org/10.1093/gerona/gly0641079-500610.1093/gerona/gly064https://hdl.handle.net/20.500.14352/92298The development of frailty scores suitable for mice and which resemble those used in the clinical scenario is of great importance to understand human frailty. The aim of the study was to determine an individual frailty score for each mouse at different ages and analyze the association between the frailty score and its lifespan. For this purpose, the “Valencia Score” for frailty was used. Thus, a longitudinal study in mice was performed analyzing weight loss, running time and speed, grip strength and motor coordination at the late-adult, mature and old ages (40, 56 and 80 weeks old, respectively). These parameters are equivalent to unintentional weight loss, poor endurance, slowness, weakness, and low activity level, respectively, in humans. A cut-off point was used to identify frail mice for each criterion. All the measurements were also performed on chronologically adult prematurely aging mice. The results show that by using the “Valencia Score” for frailty a prematurely aged phenotype can be identified even during the adulthood of animals. This opens up the possibility of carrying out preventive long-term interventions. Moreover, the individual frailty score of a given mouse at the late-adult, mature and old ages is shown to be a relevant predictor of its lifespan.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article1758-535Xhttps://doi.org/10.1093/gerona/gly064open access575591.1599.32Rate of agingLongevityExperimental modelsGenéticaFisiología animal (Biología)2409 Genética2401.13 Fisiología Animal