Paris, J.L.Vallet Regí, María Dulce Nombre2023-06-162023-06-162020-06-081999-492310.3390/pharmaceutics12060526https://hdl.handle.net/20.500.14352/6316RESEARCHER ID D-9318-2017 (Juan Luis Paris de la Fuente) ORCID 0000-0001-8950-283X (Juan Luis Paris de la Fuente) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)Mesoporous silica nanoparticles have attracted much attention in recent years as drug and gene delivery systems for biomedical applications. Among their most beneficial features for biomedicine, we can highlight their biocompatibility and their outstanding textural properties, which provide a great loading capacity for many types of cargos. In the context of cancer nanomedicine, combination therapy and gene transfection/silencing have recently been highlighted as two of its most promising fields. In this review, we aim to provide an overview of the different small molecule drug-nucleic acid co-delivery combinations that have been developed using mesoporous silica nanoparticles as carriers. By carefully selecting the chemotherapeutic drug and nucleic acid cargos to be co-delivered by mesoporous silica nanoparticles, different therapeutic goals can be achieved by overcoming resistance mechanisms, combining different cytotoxic mechanisms, or providing an additional antiangiogenic effect. The examples here presented highlight the great promise of this type of strategies for the development of future therapeutics.engAtribución 3.0 Españajournal articlehttps://doi.org/10.3390/pharmaceutics12060526https://www.ucm.es/valletregigrouphttps://www.mdpi.com/1999-4923/12/6/526open access546615.46Mesoporous silica nanoparticlesCo-deliveryDrug deliveryNucleic acidsGene transfectionNanomedicineMaterialesQuímica inorgánica (Farmacia)3312 Tecnología de Materiales