Fuertes, TeresaSalgado, IreneGarcía-Yébenes Mena, Virginia Pilar2024-01-092024-01-092021-04-19Fuertes T, Salgado I, de Yébenes VG. microRNA Fine-Tuning of the Germinal Center Response. Front Immunol. 2021 Apr 19;12:660450. doi: 10.3389/fimmu.2021.660450. PMID: 33953721; PMCID: PMC80893961664-322410.3389/fimmu.2021.660450.https://hdl.handle.net/20.500.14352/91954Germinal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma-antibody-secreting cells and memory B cells. These reactions are tightly controlled by a variety of mechanisms, including the post-transcriptional control of gene expression by microRNAs (miRNAs). Through the development of animal models with B cell-specific modified miRNA expression, we have contributed to the understanding of the role of miRNAs in the regulation of GC responses and in B cell neoplasia. Here, we review recent advances in the understanding of the role of miRNAs in the regulation of B cell and T follicular helper physiology during the GC response and in the diseases associated to GC response dysregulation.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal articlehttps://www.frontiersin.org/articles/10.3389/fimmu.2021.660450/fullhttps://pubmed.ncbi.nlm.nih.gov/33953721/open access612.017antibodiesautoimmunitygerminal centermicroRNAneoplasiaCiencias24 Ciencias de la Vida