Hurtado Carneiro, VerónicaPérez García, AnaÁlvarez García, ElviraSanz Miguel, María Del CarmenAnca Pantea Stoian2024-09-062024-09-062021-09-22Hurtado-Carneiro V, Pérez-García A, Álvarez E, et al. (2021) Role of Nutrient and Energy Sensors in the Development of Type 2 Diabetes. Type 2 Diabetes - From Pathophysiology to Cyber Systems. IntechOpen. Available at: http://dx.doi.org/10.5772/intechopen.95454.9781838819033978183881904010.5772/intechopen.95454https://hdl.handle.net/20.500.14352/107985Cell survival depends on the constant challenge to match energy demands with nutrient availability. This process is mediated through a highly conserved network of metabolic fuel sensors that orchestrate both a cellular and whole-body energy balance. A mismatch between cellular energy demand and nutrient availability is a key factor in the development of type 2 diabetes, obesity, metabolic syndrome, and other associated pathologies; thus, understanding the fundamental mechanisms by which cells detect nutrient availability and energy demand may lead to the development of new treatments. This chapter reviews the role of the sensor PASK (protein kinase with PAS domain), analyzing its role in the mechanisms of adaptation to nutrient availability and the metabolic response in different organs (liver, hypothalamus) actively cooperating to control food intake, maintain glycaemia homeostasis, and prevent insulin resistance and weight gain.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/book parthttps://www.intechopen.com/chapters/74657open access577.12PASKmTORAMPKObesityFood intakeFasting/feedingGLP-1Ciencias Biomédicas2411.08 Metabolismo Humano