Romero Martínez, Manuel AlejandroRamos Alonso, EvaLópez Muñoz, FranciscoRíos, Cristóbal de losEgea, JavierGil Martín, EmilioPita Pita, ReneTorrado Durán, Juan JoséSerrano López, Dolores RemediosJuberias, Antonio2023-06-172023-06-172021-04-102079-972110.3390/diseases9020027https://hdl.handle.net/20.500.14352/7432Blister or vesicant chemical warfare agents (CWAs) have been widely used in different military conflicts, including World War I and the Iran-Iraq War. However, their mechanism of action is not fully understood. Sulfur and nitrogen mustard exert toxic effects not only through the alkylation of thiol-bearing macromolecules, such as DNA and proteins, but also produce free radicals that can develop direct toxic effects in target organs such as the eyes, skin, and respiratory system. The lack of effective treatments against vesicant CWAs-induced injury makes us consider, in this complex scenario, the use and development of melatonin-based therapeutic strategies. This multifunctional indoleamine could facilitate neutralization of the oxidative stress, modulate the inflammatory response, and prevent the DNA damage, as well as the long-term health consequences mediated by vesicant CWAs-induced epigenetic mechanisms. In this context, it would be essential to develop new galenic formulations for the use of orally and/or topically applied melatonin for the prophylaxis against vesicant CWAs, as well as the development of post-exposure treatments in the near future.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal articlehttps://www.mdpi.com/journal/diseasesopen access615.4615.9615.357:623.459623.459:615.357Sulfur and nitrogen mustardMelatoninOxidative stressInflammationDNA damageSafetyGalenic formulationFarmaciaSalud pública (Farmacia)Tecnología farmaceúticaToxicología (Farmacia)Guerra3212 Salud Pública6113.05 Tratamiento de la Drogadicción5103.05 Guerra