Pontremolli, CarlottaIzquierdo Barba, IsabelMontalbano, GiorgiaVallet Regí, María Dulce NombreVitale-Brovarone, ChiaraFiorilli, Sonia2023-06-162023-06-162019-12-140021-979710.1016/j.jcis.2019.12.047https://hdl.handle.net/20.500.14352/5984RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba) ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)Hypothesis The treatment of bone fractures still represents a challenging clinical issue when complications due to impaired bone remodelling (i.e. osteoporosis) or infections occur. These clinical needs still require a radical improvement of the existing therapeutic approach through the design of advanced biomaterials combining the ability to promote bone regeneration with anti-adhesive properties able to minimise unspecific biomolecules adsorption and bacterial adhesion. Strontium-containing mesoporous bioactive glasses (Sr-MBG), which are able to exert a pro-osteogenic effect by releasing Sr2+ ions, have been successfully functionalised to provide mixed-charge (-NH3 /-COO⊝) surface groups with anti-adhesive abilities. Experiments Sr-MBG have been post-synthesis modified by co-grafting hydrolysable short chain silanes containing amino (aminopropylsilanetriol) and carboxylate (carboxyethylsilanetriol) moieties to achieve a zwitterionic zero-charge surface. The final system was then characterised in terms of textural-structural properties, bioactivity, cytotoxicity, pro-osteogenic and anti-adhesive capabilities. Findings After zwitterionization the in vitro bioactivity was maintained, as well as the ability to release Sr2+ ions which are capable of inducing a mineralization process. Irrespective of their size, Sr-MBG particles did not exhibit any cytotoxicity in pre-osteoblastic MC3T3-E1 up to the concentration of 75 µg/mL. Finally, the zwitterionic Sr-MBGs showed a significant reduction of serum protein adhesion with respect to the pristine ones. These results open promising future expectations in the design of nanosystems which combine pro-osteogenic and anti-adhesive properties.engjournal articlehttps://doi.org/10.1016/j.jcis.2019.12.047https://www.ucm.es/valletregigroupopen access546615.46Mesoporous Bioactive GlassesStrontium-releasing materialsZwitterionic surfacesPro-osteogenicAnti-adhesive surfacesMaterialesQuímica inorgánica (Farmacia)3312 Tecnología de Materiales