Salinero Fort, Miguel ÁngelSan Andrés Rebollo, Francisco JavierGómez Campelo, PalomaDe Burgos Lunar, CarmenCárdenas Valladolid, JuanAbánades Herranz, Juan CarlosOtero Puime, ÁngelJiménez García, RodrigoLópez De Andrés, Ana IsabelMiguel Yanes, José María De2024-01-152024-01-152017-09-01Salinero-Fort MA, San Andrés-Rebollo FJ, Gómez-Campelo P, de Burgos-Lunar C, Cárdenas-Valladolid J, Abánades-Herranz JC, Otero-Puime A, Jiménez-García R, López-de-Andrés A, de Miguel-Yanes JM; MADIABETES Research Group. Body mass index and all-cause mortality among type 2 diabetes mellitus patients: Findings from the 5-year follow-up of the MADIABETES cohort. Eur J Intern Med. 2017 Sep;43:46-5210.1016/j.ejim.2017.06.021https://hdl.handle.net/20.500.14352/92947Purpose To analyse the association between body mass index (BMI) and all-cause mortality in a 5-year follow-up study with Spanish type 2 diabetes mellitus (T2DM) patients, seeking gender differences. Methods 3443 T2DM outpatients were studied. At baseline and annually, patients were subjected to anamnesis, a physical examination, and biochemical tests. Data about demographic and clinical characteristics was also recorded, as was the treatment each patient had been prescribed. Mortality records were obtained from the Spanish National Institute of Statistics. Survival curves for BMI categories (Gehan-Wilcoxon test) and a multivariate Cox proportional hazard analysis were performed to identify adjusted Hazard Ratios (HRs) of mortality. Results Mortality rate was 26.38 cases per 1000 patient-years (95% CI, 23.92–29.01), with higher rates in men (28.43 per 1000 patient-years; 95% CI, 24.87–32.36) than in women (24.31 per 1000 patient-years; 95% CI, 21.02–27.98) (p = 0.079). Mortality rates according to BMI categories were: 56.7 (95% CI, 40.8–76.6), 28.4 (95% CI, 22.9–34.9), 24.8 (95% CI, 21.5–28.5), 21 (95% CI, 16.3–26.6) and 23.7 (95% CI, 14.3–37) per 1000 person-years for participants with a BMI of < 23, 23–26.8, 26.9–33.1, 33.2–39.4, and > 39.4 kg/m2, respectively. The BMI values associated with the highest all-cause mortality were < 23 kg/m2, but only in males [HR: 2.78 (95% CI, 1.72–4.49; p < 0.001)], since in females this association was not significant [HR: 1.14 (95% CI, 0.64–2.04; p = 0.666)] (reference category for BMI: 23.0–26.8 kg/m2). Higher BMIs were not associated with higher mortality rates. Conclusions In an outpatient T2DM Mediterranean population sample, low BMI predicted all-cause mortality only in males.engjournal articlehttps://www.sciencedirect.com/science/article/pii/S0953620517302650https://pubmed.ncbi.nlm.nih.gov/28679485/restricted access616.1/.9Body-mass indexType2 diabetes mellitusGenderMediterranean dietMortalityMedicina interna3205 Medicina Interna