Bollaín Rodríguez, JuanPulcini, AlbertoSanz Sánchez, IgnacioFiguero Ruiz, ElenaAlonso Álvarez, Bettina MaríaSanz Alonso, MarianoHerrera González, David2025-01-102025-01-102020-07-31Bollain J, Pulcini A, Sanz-Sánchez I, Figuero E, Alonso B, Sanz M, Herrera D. Efficacy of a 0.03% chlorhexidine and 0.05% cetylpyridinium chloride mouth rinse in reducing inflammation around the teeth and implants: a randomized clinical trial. Clin Oral Investig. 2021 Apr;25(4):1729-1741. doi: 10.1007/s00784-020-03474-31432-698110.1007/s00784-020-03474-3https://hdl.handle.net/20.500.14352/113648Objectives: To evaluate the efficacy of a 0.03% chlorhexidine (CHX) and 0.05% cetylpyridinium chloride (CPC) mouth rinse, as an adjunct to professional plaque removal (PPR) and mechanical hygiene, in the treatment of peri-implant mucositis (PiM) and gingivitis. Material and methods: Patients displaying PiM in, at least, one implant were included in this randomized, double-blinded, clinical trial. Subjects received PPR (at baseline and 6-month visits) and were instructed to rinse, twice daily, during 1 year with the tested mouth rinse or a placebo. Clinical and patient-reported outcomes were recorded at baseline and 6 and 12 months. Results: Fifty-four patients were included in the study and 46 attended the final visit. In the teeth and implants with inflammation, a higher reduction in BOP was observed in the test group. Statistically significant differences between groups were only observed in the lingual sites of the teeth with gingivitis (mean difference = 11.96%; 95% confidence interval [1.09; 22.83]; p = 0.03). Overall, compliance and satisfaction were good, even though staining were higher for the test group (p < 0.05). Conclusions: The combined use of mechanical debridement with a 0.03% CHX and 0.05% CPC mouth rinse may have adjunctive benefits in the management of gingivitis, and it is associated with a higher degree of staining. Clinical relevance: The control of gingivitis can be improved, after professional mechanical debridement, with toothbrushing and the supplementary use of a 0.03% CHX and 0.05% CPC mouth rinse at home.engjournal article1436-3771https://doi.org/10.1007/s00784-020-03474-332737664https://link.springer.com/article/10.1007/s00784-020-03474-3https://pubmed.ncbi.nlm.nih.gov/32737664/open access615.242615.281.9616.311.2-002616.314-089.843ChlorhexidineGingivitisMouthwashesPeri-implant mucositisOdontología (Odontología)Odontología preventivaMedicamentosImplantes dentales3213.13 Ortodoncia-Estomatología3208.02 Acción de Los Medicamentos3213 Cirugía