Puell Marín, María CintaPalomo Álvarez, CatalinaPérez Carrasco, María Jesús2023-06-172023-06-172018-110146-040410.1167/iovs.18-25334https://hdl.handle.net/20.500.14352/12953Submitted: July 19, 2018 Accepted: October 18, 2018Purpose: To examine relationships between the thicknesses of ganglion cell (GC)-related macular layers and central photopic or mesopic contrast sensitivity (CS) in healthy eyes. Methods: Measurements were made in 38 young and 38 older healthy individuals. Total, inner, and outer retinal layer (IRL) thicknesses were measured in the macula region through spectral-domain optical coherence tomography (SD-OCT) across three subfields, or rings, centered at the fovea: central foveal, pericentral, and peripheral. Ganglion cell complex and circumpapillary retinal nerve fiber layer thicknesses were also measured. Low-spatial-frequency CS for gratings presented at the central 10° visual field were measured through computerized psychophysical tests under photopic and mesopic conditions. Relationships were examined by uni- and multivariate regression analysis. Results: Peripheral IRL thickness emerged as the only independent predictor of photopic CS (P = 0.001) in the young group and of photopic (P = 0.026) and mesopic CS (P = 0.001) in the older group. The slopes of regression lines used to predict CS from peripheral IRL thickness were significantly different for pair-wise comparisons of both photopic CS and age group (P = 0.0001) and mesopic CS (P = 0.0001) and age group. These models explained 37% of the variability in photopic CS and 36% of the variability in mesopic CS. Conclusions: Macular IRL thinning likely due to GC loss was related to reduced photopic and mesopic CS in older healthy eyes. In contrast, in the young eyes, a thicker macular IRL, possibly indicating transient gliosis, was associated with reduced CS.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal articlehttp://dx.doi.org/10.1167/iovs.18-25334https://iovs.arvojournals.org/article.aspx?articleid=2715876open access617.751612.843.35Contrast sensitivityRetinal ganglion cellsOptical coherence tomographyMacular inner retinal layer thicknessMesopic visionGlial cellsDiagnóstico por imagen y medicina nuclearOftalmologíaOptometría3204.01 Medicina Nuclear3201.09 Oftalmología2209.15 Optometría