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Sun, W.L., Chen, L.L., Zhang, S.Z., Wu, Y.M., Ren, Y.Z. & Qin, G.M. 2011, "Inflammatory cytokines, adiponectin, insulin resistance and metabolic control after periodontal intervention in patients with type 2 diabetes and chronic periodontitis", Internal medicine (Tokyo, Japan), vol. 50, no. 15, pp. 1569-1574. 22. Qvarnstrom, M., Janket, S.J., Jones, J.A., Jethwani, K., Nuutinen, P., Garcia, R.I., Baird, A.E., Van Dyke, T.E. & Meurman, J.H. 2010, "Association of salivary lysozyme and C-reactive protein with metabolic syndrome", Journal of clinical periodontology, vol. 37, no. 9, pp. 805-811.https://hdl.handle.net/20.500.14352/25235Objetivos. El objetivo principal del estudio fue evaluar el efecto del tratamiento periodontal no quirúrgico sobre los marcadores inflamatorios sistémicos en pacientes con SMet, analizando los niveles de CRP, Alfa-1 antitripsina y fibrinógeno en plasma. Los objetivos secundarios fueron determinar el impacto del tratamiento periodontal sobre el metabolismo de los lípidos y carbohidratos, mediante el análisis de los cambios en la hemoglobina glicosilada (HbA1c) en plasma, los triglicéridos, el colesterol sérico total, lipoproteínas de alta densidad (HDL) y lipoproteínas de baja densidad (LDL). Material y Métodos. Se realizó un ensayo clínico aleatorizado, con doble ciego y una duración de 6 meses a pacientes con periodontitis y síndrome metabólico. Los participantes fueron seleccionados de manera aleatoria para su inclusión en el grupo tratamiento (n= 7), al que se le realizó un tratamiento periodontal intensiva (IPT) o en el grupo control (n= 9), donde se llevó a cabo un tratamiento periodontal mínimo (MPT). Resultados. Se realizó examen periodontal a 151 pacientes con diagnóstico de síndrome metabólico. De los cuales un total de 20 llegaron a ser objeto de aleatorización y 16 de ellos asistieron a todas las visitas del estudio. Se encontraron diferencias significativas entre los grupos a nivel basal en proteína C reactiva, alfa-1 antitripsina y fibrinógeno (p≤0.05). No se encontraron diferencias estadísticamente significativas entre ambos grupos en los valores de proteína C reactiva, alfa-1 antitripsina y fibrinógeno, no obstante, la diferencia en la disminución de la proteína C reactiva mostró un valor cercano a la significación estadística (p= 0.698) Conclusión La disminución de los valores de marcadores inflamatorios sistémicos (proteína C reactiva, alfa-1 antitripsina y fibrinógeno) en el suero no se pudo demostrar debido al reducido tamaño de la muestra.spamaster thesisopen access616.314.17-008.1Enfermedad periodontalPeriodontal diseasePeriodoncia3213.13 Ortodoncia-Estomatología