López Cuenca, InésMarcos Dolado, AlbertoYus Fuertes, MiguelGarcía Martín, Elena SalobrarElvira Hurtado, LorenaFernández Albarral, JoséSalazar Corral, Juan JoséRamírez Sebastián, Ana IsabelSánchez-Puebla Fernández, LidiaFuentes Ferrer, Manuel EnriqueBarabash Bustelo, AnaRamírez Toraño, FedericoGil Martínez, LidiaArrazola García, Juan LorenzoGil Gregorio, PedroHoz Montañana, María Rosa DeRamírez Sebastián, José Manuel2023-06-222023-06-222022-06-04López Cuenca, I., Marcos Dolado, A., Yus Fuertes, M. et al. «The Relationship between Retinal Layers and Brain Areas in Asymptomatic First-Degree Relatives of Sporadic Forms of Alzheimer’s Disease: An Exploratory Analysis». Alzheimer’s Research & Therapy, vol. 14, n.o 1, diciembre de 2022, p. 79. DOI.org (Crossref), https://doi.org/10.1186/s13195-022-01008-5.1758-919310.1186/s13195-022-01008-5https://hdl.handle.net/20.500.14352/71698Background: Two main genetic risks for sporadic Alzheimer’s disease (AD) are a family history and ɛ4 allele of apolipoprotein E. The brain and retina are part of the central nervous system and share pathophysiological mechanisms in AD. Methods: We performed a cross-sectional study with 30 participants without a family history of sporadic AD (FH−) and noncarriers of ApoE ɛ4 (ApoE ɛ4−) as a control group and 34 participants with a family history of sporadic AD (FH+) and carriers of at least one ɛ4 allele (ApoE ɛ4+). We analyzed the correlations between macular volumes of retinal layers and thickness of the peripapillary retinal nerve fiber layer (pRNFL) measured by optical coherence tomography (OCT) with the brain area parameters measured by magnetic resonance imaging (MRI) in participants at high genetic risk of developing AD (FH+ ApoE ɛ4+). Results: We observed a significant volume reduction in the FH+ ApoE ɛ4+ group compared with the control group in some macular areas of (i) macular RNFL (mRNFL), (ii) inner plexiform layer (IPL), (iii) inner nuclear layer (INL), and (iv) outer plexiform layer (OPL). Furthermore, in the FH+ ApoE ɛ4+ group, the retinal sectors that showed statistically significant volume decrease correlated with brain areas that are affected in the early stages of AD. In the same group, the peripapillary retinal nerve fiber layer (pRNFL) did not show statistically significant changes in thickness compared with the control group. However, correlations of these sectors with the brain areas involved in this disease were also found. Conclusions: In cognitively healthy participants at high genetic risk of developing sporadic forms of AD, there are significant correlations between retinal changes and brain areas closely related to AD such as the entorhinal cortex, the lingual gyrus, and the hippocampus.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal articlehttps://doi.org/10.1186/s13195-022-01008-5https://alzres.biomedcentral.com/articles/10.1186/s13195-022-01008-5open access616.894-053.9611.843:616.9617.735-073.75Alzheimer’s diseaseFamily historyApoE ɛ4RetinaOCTMRIBrainGenética médicaNeurociencias (Medicina)OftalmologíaAnatomía ocularTécnicas de la imagen2410.07 Genética Humana2490 Neurociencias3201.09 Oftalmología