López-Olañeta, Marina M.Villalba Orero, MaríaGómez-Salinero, Jesús M.Jiménez-Borreguero, Luis J.Breckenridge, RossOrtiz Sánchez, PaulaGarcía-Pavía, PabloIbáñez, BorjaLara-Pezzi, Enrique2024-01-252024-01-252014Marina M. López-Olañeta, María Villalba, Jesús M. Gómez-Salinero, Luis J. Jiménez-Borreguero, Ross Breckenridge, Paula Ortiz-Sánchez, Pablo García-Pavía, Borja Ibáñez, Enrique Lara-Pezzi, Induction of the calcineurin variant CnAβ1 after myocardial infarction reduces post-infarction ventricular remodelling by promoting infarct vascularization, Cardiovascular Research, Volume 102, Issue 3, 1 June 2014, Pages 396–406, https://doi.org/10.1093/cvr/cvu0681755-324510.1093/cvr/cvu068https://hdl.handle.net/20.500.14352/95565Ventricular remodelling following myocardial infarction progressively leads to loss of contractile capacity and heart failure. Although calcineurin promotes maladaptive cardiac hypertrophy, we recently showed that the calcineurin splicing variant, CnAβ1, has beneficial effects on the infarcted heart. However, whether this variant limits necrosis or improves remodelling is still unknown, precluding translation to the clinical arena. Here, we explored the effects and therapeutic potential of CnAβ1 overexpression post-infarction.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article0008-6363https://doi.org/10.1093/cvr/cvu06824667850https://academic.oup.com/cardiovascres/article/102/3/396/2931078?login=truehttps://pubmed.ncbi.nlm.nih.gov/24667850/restricted access61CnAb1AktCardiac remodellingMyocardial infarctionCalcineurinVeterinaria2401 Biología Animal (Zoología)