Neto, Francisco Simãoda Silva Sousa, PatrickFernandes Melo, Rafael Leandrode Castro Bizerra, VivianeDari, Dayana Nascimentodos Santos, Kaiany Moreirade Sousa Junior, Paulo Gonçalvesda Silva, Jessica LopesFernández Lucas, Jesúsda Silva Aires, Francisco Izaiasde Sousa Rios, Maria AlexsandraTaherzadeh, Mohammad J.Sousa dos Santos, José Cleiton2025-09-232025-09-232025-08Neto, F. S., da Silva Sousa, P., Fernandes Melo, R. L., de Castro Bizerra, V., Dari, D. N., dos Santos, K. M., de Sousa Junior, P. G., da Silva, J. L., Fernández-Lucas, J., da Silva Aires, F. I., de Sousa Rios, M. A., Taherzadeh, M. J., & Sousa dos Santos, J. C. (2025). [Rev. of Exploring molecular catalysis in the enzymatic synthesis of biolubricants: A comprehensive review and bibliometric assessment]. Molecular Catalysis, 583. https://doi.org/10.1016/J.MCAT.2025.1151912468-827410.1016/j.mcat.2025.115191https://hdl.handle.net/20.500.14352/124222We gratefully acknowledge the following Brazilian agencies for scientific and technological development: Fundaçao Cearense de Apoio ao Desenvolvimento Científico e Tecnologico (FUNCAP) (PS1-0186- 00216.01.00/21; 31052.000417/2023; UNI-0210-00537.01.00/23), Conselho Nacional de Desenvolvimento Científico e Tecnologico (CNPq) (311062/2019-9; 774 440891/2020-5; 307454/2022-3), and Coordenaçao de Aperfeiçoamento de Ensino Superior (CAPES) (finance code 001).Biolubricants are produced from renewable biological raw materials using sustainable methods, such as enzymatic catalysis and the esterification of vegetable oils and animal fats, representing a promising alternative. Enzymatic biocatalysts, in particular, have high specificity in synthesizing new products, making them a fundamental tool in producing biolubricants. This study aims to conduct a detailed bibliometric analysis to evaluate the primary studies on the enzymatic synthesis of biolubricants. It also identifies prominent countries, authors, journals, and research areas contributing to the topic. Describe the characteristics, advantages, and challenges associated with biolubricants, including the types of enzymes, substrates, and raw materials used, the mechanisms of enzymatic synthesis, and the techniques used for production, optimization, and characterization. The keywords "biofuel", "biolubricant" and "enzyme" were used for the database. The search was carried out in Scopus, covering the period from 2014 to June 2024. The analysis returned 358 articles and revealed significant international collaboration, especially between Brazil, India, and China. Brazil leads the field, contributing 19.27 % of the publications. Brazilian institutions have shown remarkable specialization in producing lubricants, using the country's rich biodiversity and biomass resources to promote research and innovation. Thus, this study presents a complete contextualization of the production of biolubricants, with an overview of world production in the area and a literature review that addresses relevant topics such as production routes and product analysis.engjournal article2468-8231https://doi.org/10.1016/j.mcat.2025.115191https://www.sciencedirect.com/science/article/pii/S2468823125003761?via%3Dihubrestricted access577.1566.0504621.892002.2:519.23BiolubricantEnzymesBibliometric analysisBioquímica (Biología)Ecología (Biología)BibliometríaMedio ambiente2403 Bioquímica2391 Química Ambiental2210.01 Catálisis2302.09 Enzimología3321.06 Aceite y Grasa Lubricantes