Gómez Mejía, EstherVicente Zurdo, DavidRosales Conrado, NoeliaLeón González, María Eugenia de2024-10-182024-10-182024https://doi.org/10.1016/j.foodchem.2024.141208https://hdl.handle.net/20.500.14352/109089Wild fruits, particularly the underutilized sloe (Prunus spinosa), are gaining interest as natural antioxidants, with residues from liqueur production being a source of bioactive compounds. This study proposes a sustainable approach for valorizing sloe residues, seeds and skins, by employing an innovative green extraction method. HPLC-ESI-QTOF and spectrophotometric techniques were used to explore the phenolic profile, highlighting the predominance of quercetin, 2,3-dihydroxybenzoic and ferulic acids (9.7–57 μg·g−1). In addition, the presence of Cu, Zn and Ca was confirmed by atomic absorption spectroscopy. Simultaneously, their neuroprotective potential against Alzheimer's disease (AD) was studied by exploring the inhibition of beta-amyloid aggregation and oxidative stress cytoprotection in SH-SY5Y cell line, standing out 1 μg·g−1 and 10 μg·g−1 extracts of sloe skin. Phenolic composition was correlated with bioactivities by means of multivariate analysis. These results contributed to highlight the potential of this bio-residue as a neuroprotective agent against AD in pharmaceutical and nutraceutical industries.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://doi.org/10.1016/j.foodchem.2024.141208https://www.sciencedirect.com/science/article/pii/S0308814624028589?via%3Dihubopen access543Sloe bio-residuesCircular economyPolyphenolsAlzheimer's diseaseIn vitro antioxidantAβ42Chemometric toolsQuímica analítica (Química)Neurociencias (Farmacia)2301 Química Analítica